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Literature summary extracted from

  • Okada, N.N.; Ishizuka, T.; Isogai, E.; Suzuki, N.; Tatibana, M.
    Variation of phosphoribosylpyrophosphate synthetase activity in human cells (1998), Biochem. Mol. Biol. Int., 44, 1059-1067.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate Homo sapiens the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
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 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.6.1 fibroblast cell line fetal, RSa cells, UV sensitive clonal cells Homo sapiens
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.6.1 additional information
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 the enzyme activity rises at the start of the S phase of the cell cycle, apparently in association with the rate of DNA synthesis Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Homo sapiens AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Homo sapiens AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.6.1 37
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 assay at Homo sapiens