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Literature summary extracted from

  • Parry, R.J.; Burns, M.R.; Skae, P.N.; Hoyt, J.C.; Pal, B.
    Carbocyclic analogues of D-ribose-5-phosphate: synthesis and behavior with 5-phosphoribosyl alpha-1-pyrophosphate synthetases (1996), Bioorg. Med. Chem., 4, 1077-1088.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.1 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate mixed-type inhibition with respect to D-ribose 5-phosphate and no inhibition against ATP Bacillus subtilis
2.7.6.1 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate at pH 7.5, competitive inhibition with respect to D-ribose 5-phosphate and noncompetitive inhibition with respect to ATP Homo sapiens
2.7.6.1 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate at pH 7.5, competitive inhibition with respect to D-ribose 5-phosphate and noncompetitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate partial noncompetitive inhibition with respect to D-ribose 5-phosphate and no inhibition with respect to ATP Homo sapiens
2.7.6.1 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate partial mixed-type inhibition with respect to D-ribose 5-phosphate and ATP Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.6.1 0.135
-
 D-ribose 5-phosphate pH 8.0, 37ºC Homo sapiens
2.7.6.1 0.14
-
 ATP pH 8.0, 37ºC Homo sapiens
2.7.6.1 0.193
-
 ATP pH 8.0, 37ºC Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 0.298
-
 D-ribose 5-phosphate pH 8.0, 37ºC Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 0.791
-
 D-ribose 5-phosphate pH 8.0, 37ºC Bacillus subtilis
2.7.6.1 1.127
-
 ATP pH 8.0, 37ºC Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate Bacillus subtilis the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate Homo sapiens the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Bacillus subtilis
-
-
-
2.7.6.1 Homo sapiens
-
-
-
2.7.6.1 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate very poor substrate Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.7.6.1 ATP + 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate very poor substrate Homo sapiens ?
-
 ?
2.7.6.1 ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate very poor substrate, better than 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.7.6.1 ATP + 1,4,5-trihydroxy-3-cyclopent-2-enemethanol-6-phosphate very poor substrate, better than 1,2,3-trihydroxy-4-cyclopentanemethanol-6-phosphate Homo sapiens ?
-
 ?
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Bacillus subtilis AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Homo sapiens AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Bacillus subtilis AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Homo sapiens AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.6.1 37
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.6.1 7
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 7
-
-
 Homo sapiens