EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.6.1 | ADP | non competitive with respect to ATP at 0.2 mM D-ribose-5-phosphate; the most effective | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | Ca2+ | low concentrations of CaCl2 in the presence of an excess of MgCl2 result in a reduction in catalytic activity. At CaCl2 1 mM, the enzyme is less sensitive to ADP inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | CTP | the most effective pyrimidine nucleotide inhibitor | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | D-fructose 1,6-diphosphate | no inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | D-Fructose 1-phosphate | no inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | D-ribose 5-phosphate | inhibition in presence of Ca2+, without ADP; substrate inhibition in presence of ADP, not in its absence | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | dADP | induces substrate inhibition by D-ribose-5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | GDP | below 3-4 mM, linear competitive inhibition with respect to ATP | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | GTP | below 3-4 mM, linear competitive inhibition with respect to ATP | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | IDP | below 3-4 mM, linear competitive inhibition with respect to ATP | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | ITP | below 3-4 mM, linear competitive inhibition with respect to ATP | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | L-histidine | no inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | L-tryptophan | no inhibition | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | additional information | 6-phosphogluconate, 3-phosphoglycerate, phosphoenolpyruvate and ribulose-5-phosphate have no effect on the activity; D-glucose-6-phosphate have no effects on the enzyme activity; purines are more effective than pyrimidines, nucleoside tri and diphosphates are more effective than monophosphates, ribonucleotides are more effective than deoxynucleotides | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | nucleotides | purines more effective than pyrimidines | Salmonella enterica subsp. enterica serovar Typhimurium | |
2.7.6.1 | UDP | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.6.1 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.6.1 | ATP + D-ribose 5-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r | |
2.7.6.1 | ATP + D-ribose 5-phosphate | the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan | Salmonella enterica subsp. enterica serovar Typhimurium | AMP + 5-phospho-alpha-D-ribose 1-diphosphate | - |
r |