Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Switzer, R.L.; Sogin, D.C.
    Regulation and mechanism of phosphoribosylpyrophosphate synthetase. V. Inhibition by end products and regulation by adenosine diphosphate (1973), J. Biol. Chem., 248, 1063-1073.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.1 ADP non competitive with respect to ATP at 0.2 mM D-ribose-5-phosphate; the most effective Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 Ca2+ low concentrations of CaCl2 in the presence of an excess of MgCl2 result in a reduction in catalytic activity. At CaCl2 1 mM, the enzyme is less sensitive to ADP inhibition Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 CTP the most effective pyrimidine nucleotide inhibitor Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 D-fructose 1,6-diphosphate no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 D-Fructose 1-phosphate no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 D-ribose 5-phosphate inhibition in presence of Ca2+, without ADP; substrate inhibition in presence of ADP, not in its absence Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 dADP induces substrate inhibition by D-ribose-5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 GDP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 GTP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 IDP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 ITP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 L-histidine no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 L-tryptophan no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 additional information 6-phosphogluconate, 3-phosphoglycerate, phosphoenolpyruvate and ribulose-5-phosphate have no effect on the activity; D-glucose-6-phosphate have no effects on the enzyme activity; purines are more effective than pyrimidines, nucleoside tri and diphosphates are more effective than monophosphates, ribonucleotides are more effective than deoxynucleotides Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 nucleotides purines more effective than pyrimidines Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 UDP
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r