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Literature summary extracted from

  • Schubert, K.R.; Switzer, R.L.; Shelton, E.
    Studies of the quaternary structure and the chemical properties of phosphoribosylpyrophosphate synthetase from Salmonella typhimurium (1975), J. Biol. Chem., 250, 7492-7500.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.6.1 additional information
-
 enzyme occurs in multiple states of aggregation Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 30400
-
 x * 30400, sedimentation equilibrium analysis of enzyme dissociated in 6 M guanidine hydrochloride Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 33800
-
 x * 33800, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 160000
-
 ultracentrifugation Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 200000 340000 sucrose density gradient sedimentation Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 310000
-
 gel filtration Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium Su 422 the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Salmonella enterica subsp. enterica serovar Typhimurium
-
 Su 422 strain
-
2.7.6.1 Salmonella enterica subsp. enterica serovar Typhimurium Su 422
-
 Su 422 strain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.6.1 ammonium sulfate fractionation Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium Su 422 AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r
2.7.6.1 ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium Su 422 AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.6.1 ? x * 30400, sedimentation equilibrium analysis of enzyme dissociated in 6 M guanidine hydrochloride Salmonella enterica subsp. enterica serovar Typhimurium
2.7.6.1 ? x * 33800, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium