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Literature summary extracted from

  • Miller, W.H.; Beauchamp, L.M.; Meade, E.; Reardon, J.E.; Biron, K.K.; Smith, A.A.; Goss, C.A.; Miller, R.L.
    Phosphorylation of ganciclovir phosphonate by cellular GMP kinase determines the stereoselectivity of anti-human cytomegalovirus activity (2000), Nucleosides Nucleotides Nucleic Acids, 19, 341-356.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.8 0.026
-
 GMP pH 7.5, 37ºC Homo sapiens
2.7.4.8 0.03
-
 dGMP pH 7.5, 37ºC Homo sapiens
2.7.4.8 0.047
-
 ganciclovir monophosphate pH 7.5, 37ºC Homo sapiens
2.7.4.8 0.052
-
 (R)-ganciclovir phosphonate pH 7.5, 37ºC Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.8 Homo sapiens
-
-
-
2.7.4.8 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.8 brain
-
 Sus scrofa
-
2.7.4.8 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.8 ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution Homo sapiens (R)-ganciclovir phosphonate monophosphate
-
 ?
2.7.4.8 ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid i.e. R-ganciclovir phosphonate, (S) enantiomer 100fold less efficient, used for racemic resolution Sus scrofa (R)-ganciclovir phosphonate monophosphate
-
 ?
2.7.4.8 ATP + (R)-ganciclovir phosphonate
-
 Homo sapiens ?
-
 ?
2.7.4.8 ATP + ganciclovir monophosphate
-
 Homo sapiens ?
-
 ?