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Literature summary extracted from

  • Hughes, T.L.; Hahn, T.M.; Reynolds, K.K.; Shewach, D.S.
    Kinetic analysis of human deoxycytidine kinase with the true phosphate donor uridine triphosphate (1997), Biochemistry, 36, 7540-7547.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.74 ATP substrate activation, at high concentrations of deoxycytidine Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 dCMP
-
Homo sapiens
2.7.1.74 dCTP
-
Homo sapiens
2.7.1.74 deoxycytidine at concentrations greater than 0.003 mM, UTP as substrate, noncompetitive Homo sapiens
2.7.1.74 UDP
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.74 0.0005
-
UTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.0009
-
GTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.001
-
ATP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.001
-
dTTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.0013
-
CTP cosubstrate 2'-deoxycytidine, 37°C, pH 7.4 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.74 NTP + deoxycytidine = NDP + dCMP mechanism Homo sapiens
2.7.1.74 NTP + deoxycytidine = NDP + dCMP ordered A-B random B-Q reaction sequence Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 CTP + 2'-deoxycytidine
-
Homo sapiens CDP + 2'-deoxy-CMP
-
?
2.7.1.74 dTTP + 2'-deoxycytidine
-
Homo sapiens dTDP + 2'-deoxy-CMP
-
?
2.7.1.74 GTP + 2'-deoxycytidine
-
Homo sapiens GDP + 2'-deoxy-CMP
-
?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.74 0.0004
-
UDP cosubstrate UTP, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.0015
-
dCMP cosubstrate UTP, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.0069
-
UDP cosubstrate deoxycytidine, 37°C, pH 7.4 Homo sapiens
2.7.1.74 0.022
-
dCMP cosubstrate deoxycytidine, 37°C, pH 7.4 Homo sapiens