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Literature summary extracted from

  • Johansson, M.; Karlsson, A.
    Differences in kinetic properties of pure recombinant human and mouse deoxycytidine kinase (1995), Biochem. Pharmacol., 50, 163-168.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.74
-
 Mus musculus
2.7.1.74
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 dCTP at 0.013 mM, substrates ATP, deoxycytosine, 30% inhibition Homo sapiens
2.7.1.74 dCTP at 0.013 mM, substrates ATP, deoxycytosine, 50% inhibition Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.74 0.00005
-
 2'-deoxycytidine cosubstrate UTP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.0001
-
 2'-deoxycytidine cosubstrate UTP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.00016
-
 2'-deoxycytidine cosubstrate ATP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.00018
-
 2'-deoxycytidine cosubstrate ATP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.00099
-
 2-chloro-2'-deoxyadenosine cosubstrate UTP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.0063
-
 2-chloro-2'-deoxyadenosine cosubstrate UTP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.017
-
 2-chloro-2'-deoxyadenosine cosubstrate ATP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.019
-
 2'-deoxyadenosine cosubstrate UTP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.024
-
 2-chloro-2'-deoxyadenosine cosubstrate ATP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.15
-
 2'-deoxyadenosine cosubstrate UTP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.15
-
 2',3'-dideoxycytidine cosubstrate UTP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.23
-
 2',3'-dideoxycytidine cosubstrate ATP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.48
-
 2',3'-dideoxycytidine cosubstrate UTP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.48
-
 2'-deoxyadenosine cosubstrate ATP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 0.55
-
 2'-deoxyadenosine cosubstrate ATP, 37°C, pH 7.6 Mus musculus
2.7.1.74 0.67
-
 2',3'-dideoxycytidine cosubstrate ATP, 37°C, pH 7.6 Mus musculus
2.7.1.74 2
-
 9-beta-D-arabinofuranosylguanine cosubstrate UTP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 3
-
 9-beta-D-arabinofuranosylguanine cosubstrate UTP, 37°C, pH 7.6 Mus musculus
2.7.1.74 3
-
 9-beta-D-arabinofuranosylguanine cosubstrate ATP, 37°C, pH 7.6 Homo sapiens
2.7.1.74 5
-
 9-beta-D-arabinofuranosylguanine cosubstrate ATP, 37°C, pH 7.6 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-
2.7.1.74 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 2-chloro-2'-deoxyadenosine + NTP
-
 Mus musculus NDP + 2-chloro-2'-deoxy-AMP
-
 ?
2.7.1.74 2-chloro-2'-deoxyadenosine + NTP
-
 Homo sapiens NDP + 2-chloro-2'-deoxy-AMP
-
 ?
2.7.1.74 9-beta-D-arabinofuranosylguanine + NTP
-
 Mus musculus NDP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
-
 ?
2.7.1.74 9-beta-D-arabinofuranosylguanine + NTP
-
 Homo sapiens NDP + 9-beta-D-arabinofuranosylguanine 5'-phosphate
-
 ?
2.7.1.74 NTP + 2',3'-dideoxycytidine
-
 Mus musculus NDP + 2',3'-dideoxycytidine 5'-phosphate
-
 ?
2.7.1.74 NTP + 2',3'-dideoxycytidine
-
 Homo sapiens NDP + 2',3'-dideoxycytidine 5'-phosphate
-
 ?
2.7.1.74 NTP + deoxyadenosine
-
 Mus musculus NDP + dAMP
-
 ?
2.7.1.74 NTP + deoxyadenosine
-
 Homo sapiens NDP + dAMP
-
 ?
2.7.1.74 NTP + deoxycytidine
-
 Mus musculus NDP + dCMP
-
 ?
2.7.1.74 NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?