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Literature summary extracted from

  • Shewach, D.S.; Reynolds, K.K.; Hertel, L.
    Nucleotide specificity of human deoxycytidine kinase (1992), Mol. Pharmacol., 42, 518-524.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.74 dCTP no inhibition at physiological concentrations Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 leukemia cell leukemic T-lymphoblasts Homo sapiens
-
2.7.1.74 leukemia cell cell line MOLT-4 Homo sapiens
-
2.7.1.74 MOLT-4 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 NTP + 2',2'-difluoro-2'-deoxycytidine best acceptor substrate, best phosphate donors: UTP or NTP-mixture, better than ATP Homo sapiens NDP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 NTP + 9-beta-D-arabinofuranosyl-2-fluoroadenine
-
 Homo sapiens NDP + 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate
-
 ?
2.7.1.74 NTP + cytosine arabinoside D-isomer Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
 ?
2.7.1.74 NTP + cytosine arabinoside best phosphate donors: UTP or NTP-mixture, even better than ATP Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
 ?
2.7.1.74 NTP + deoxycytidine enzyme shows little specificity towards phosphate donor Homo sapiens NDP + dCMP
-
 ?
2.7.1.74 UTP + 2'-deoxycytidine as good as CTP, GTP or dATP Homo sapiens UDP + 2'-deoxy-CMP
-
 ?