BRENDA - Enzyme Database

Legionella micdadei protein kinase catalyzes phosphorylation of tubulin and phosphatidylinositol

Saha, A.K.; Dowling, J.N.; Mukhopadhyay, N.K.; Glew, R.H.; J. Bacteriol. 171, 5103-5110 (1989)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.67
octyl beta-D-glucoside
10-20 mM, stimulates
Tatlockia micdadei
2.7.1.67
Triton X-100
0.25-0.5%, stimulates
Tatlockia micdadei
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.67
phosphatidylcholine
0.6 mM, 45% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylethanolamine
0.6 mM, 67% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylglycerol
0.6 mM, 68% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylinositol 4,5-bisphosphate
0.6 mM, 50% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylinositol 4-phosphate
0.6 mM, 80% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylserine
0.6 mM, 28% inhibition
Tatlockia micdadei
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.67
1.5
-
ATP
pH 7.2, 37°C
Tatlockia micdadei
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.67
Ca2+
divalent cation requirement is best satisfied by Mg2+ and Ca2+
Tatlockia micdadei
2.7.1.67
Mg2+
divalent cation requirement is best satisfied by Mg2+ and Ca2+
Tatlockia micdadei
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.67
Tatlockia micdadei
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.67
ATP + 1-phosphatidyl-1D-myo-inositol
-
641799
Tatlockia micdadei
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.1.67
7
-
-
Tatlockia micdadei
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.7.1.67
octyl beta-D-glucoside
10-20 mM, stimulates
Tatlockia micdadei
2.7.1.67
Triton X-100
0.25-0.5%, stimulates
Tatlockia micdadei
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.1.67
phosphatidylcholine
0.6 mM, 45% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylethanolamine
0.6 mM, 67% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylglycerol
0.6 mM, 68% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylinositol 4,5-bisphosphate
0.6 mM, 50% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylinositol 4-phosphate
0.6 mM, 80% inhibition
Tatlockia micdadei
2.7.1.67
phosphatidylserine
0.6 mM, 28% inhibition
Tatlockia micdadei
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.7.1.67
1.5
-
ATP
pH 7.2, 37°C
Tatlockia micdadei
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.67
Ca2+
divalent cation requirement is best satisfied by Mg2+ and Ca2+
Tatlockia micdadei
2.7.1.67
Mg2+
divalent cation requirement is best satisfied by Mg2+ and Ca2+
Tatlockia micdadei
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.67
ATP + 1-phosphatidyl-1D-myo-inositol
-
641799
Tatlockia micdadei
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.7.1.67
7
-
-
Tatlockia micdadei