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Literature summary extracted from

  • Husebye, E.S.; Flatmark, T.
    Phosphatidylinositol kinase of bovine adrenal chromaffin granules: kinetic properties and inhibition by low concentrations of Ca2+ (1988), Biochim. Biophys. Acta, 968, 261-265.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 Ca2+ reversibly inhibited by free Ca2+ in the nanomolar and low micromolar range, dependening on the concentration of Mg2+ Bos taurus
2.7.1.67 KCl slight inhibition Bos taurus
2.7.1.67 NaCl slight inhibition Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.67 0.044
-
 ATP in presence of 1 mM MgCl2 Bos taurus
2.7.1.67 0.044
-
 ATP ATP in form of MgATP2- Bos taurus
2.7.1.67 0.062
-
 ATP in presence of 20 mM MgCl2 Bos taurus
2.7.1.67 0.062
-
 ATP ATP in form of MgATP2- Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 chromaffin granule
-
 Bos taurus 42583
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ highly dependent on Mg2+, maximal stimulation at 60 mM Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Bos taurus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?