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Literature summary extracted from

  • Miyajima, R.; Shiio, I.
    Regulation of aspartate family amino acid biosynthesis in Brevibacterium flavum. V. Properties of homoserine kinase (1972), J. Biochem., 71, 219-226.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.39 NH4+ not essential, but stimulates [Brevibacterium] flavum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.39 L-Thr 8.1 mM, 50% inhibition [Brevibacterium] flavum
2.7.1.39 phosphohomoserine inhibits phosphorylation of L-homoserine [Brevibacterium] flavum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.39 0.77
-
L-homoserine pH 7.5, 30°C [Brevibacterium] flavum
2.7.1.39 1.2
-
ATP pH 7.5, 30°C [Brevibacterium] flavum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.39 K+ 200 mM, enhances activity about twice [Brevibacterium] flavum
2.7.1.39 Mg2+ stimulates [Brevibacterium] flavum
2.7.1.39 Mn2+ can replace Mg2+ in stimulation [Brevibacterium] flavum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.39 55000
-
gel filtration [Brevibacterium] flavum

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.39 [Brevibacterium] flavum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.39 partial [Brevibacterium] flavum

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.39 ATP + L-homoserine = ADP + O-phospho-L-homoserine rapid equilibrium random bi bi mechanism [Brevibacterium] flavum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.39 0.293
-
-
[Brevibacterium] flavum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.39 ATP + L-homoserine
-
[Brevibacterium] flavum ADP + O-phospho-L-homoserine
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.39 7.4
-
Tris buffer [Brevibacterium] flavum