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Literature summary extracted from

  • Vallari, D.S.; Jackowski, S.; Rock, C.O.
    Regulation of pantothenate kinase by coenzyme A and its thioesters (1987), J. Biol. Chem., 262, 2468-2471.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.33 dithiothreitol activation Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.33 acetoacetyl-CoA
-
 Escherichia coli
2.7.1.33 acetyl-CoA
-
 Escherichia coli
2.7.1.33 ADP
-
 Escherichia coli
2.7.1.33 AMP
-
 Escherichia coli
2.7.1.33 CoA in vitro; in vivo; kinetics Escherichia coli
2.7.1.33 dephospho-CoA not Escherichia coli
2.7.1.33 malonyl-CoA
-
 Escherichia coli
2.7.1.33 additional information not inhibitory: 3',5'-ADP; not inhibitory: cAMP, NADH, NADPH, CoA:glutathione disulfide; not inhibitory: NAD+ Escherichia coli
2.7.1.33 palmitoyl-CoA
-
 Escherichia coli
2.7.1.33 pantetheine 4'-phosphate not Escherichia coli
2.7.1.33 succinyl-CoA
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.33 0.009
-
 pantothenate
-
 Escherichia coli
2.7.1.33 0.225
-
 ATP pH 7.4, 25°C Escherichia coli
2.7.1.33 0.225
-
 ATP ATP in form of MgATP2- Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.33 cytosol
-
 Escherichia coli 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.33 Mg2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.33 ATP + D-pantothenate Escherichia coli first and rate-controlling reaction of CoA-biosynthesis ADP + D-4'-phosphopantothenate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.33 Escherichia coli
-
 K-12 strains UB 1005, SJ16, DV1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.33 strain SJ16, partial Escherichia coli

Storage Stability

EC Number Storage Stability Organism
2.7.1.33 -20°C, partially purified preparation, several months Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.33 ATP + (R)-pantothenate
-
 Escherichia coli ADP + (R)-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate poor phosphate donor: alpha,beta-methyleneadenosine 5'-triphosphate Escherichia coli ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate transfers the gamma-phosphate of ATP to pantothenate Escherichia coli ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 ATP + D-pantothenate first and rate-controlling reaction of CoA-biosynthesis Escherichia coli ADP + D-4'-phosphopantothenate
-
 ?
2.7.1.33 GTP + pantothenate phosphorylation at 20% the rate of ATP Escherichia coli GDP + D-4'-phosphopantothenate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.33 25
-
 assay at Escherichia coli