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Literature summary extracted from

  • Venkatachalam, K.V.
    Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency (2003), IUBMB Life, 55, 1-11.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.25 G427A
-
 Homo sapiens
2.7.1.25 G79R reduced APS kinase activity Mus musculus
2.7.1.25 H425A
-
 Homo sapiens
2.7.1.25 H428A
-
 Homo sapiens
2.7.1.25 N426K
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.25 ATP + adenosine 5-phosphosulfate Mus musculus enzyme is involved in sulfation of cartilaginous chondroitin sulfate, reduced enzyme activity causes brachymorphism ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?
2.7.1.25 ATP + adenosine 5-phosphosulfate Homo sapiens PAPSS 1 is essential for the sulfonation of mucin like glycoproteins such as GlyCAM-1, CD34 and MAdCAM-1 in high endothelial venules ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.25 Caenorhabditis elegans
-
-
-
2.7.1.25 Cavia porcellus O54820 guinea pig, isoenzyme PAPSS 1
-
2.7.1.25 Danio rerio Q802U9 zebra fish
-
2.7.1.25 Drosophila melanogaster Q9VW48
-
-
2.7.1.25 Homo sapiens
-
-
-
2.7.1.25 Homo sapiens O43252 PAPSS 1
-
2.7.1.25 Homo sapiens O95340 isoenzyme PAPSS 2
-
2.7.1.25 Homo sapiens O95340 isoenzyme PAPSS 2b, splice variant of PAPSS2, several SNPs and polymorphisms are identified with reference to PAPSS 1 and 2
-
2.7.1.25 Mus musculus
-
 isoenzymes PAPS 1 and 2
-
2.7.1.25 Takifugu rubripes Q90XY2 puffer fish
-
2.7.1.25 Urechis caupo Q27128
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.25 brain
-
 Homo sapiens
-
2.7.1.25 brain high expression of PAPSS 1 Homo sapiens
-
2.7.1.25 cartilage
-
 Homo sapiens
-
2.7.1.25 cartilage high expression of PAPSS 2 Homo sapiens
-
2.7.1.25 liver
-
 Homo sapiens
-
2.7.1.25 liver predominantly PAPS2 Homo sapiens
-
2.7.1.25 liver high expression of PAPSS 2 Homo sapiens
-
2.7.1.25 skin PAPSS 1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Mus musculus ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Urechis caupo ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Cavia porcellus ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Candida elegans ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Drosophila melanogaster ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Danio rerio ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Takifugu rubripes ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?
2.7.1.25 ATP + adenosine 5-phosphosulfate enzyme is involved in sulfation of cartilaginous chondroitin sulfate, reduced enzyme activity causes brachymorphism Mus musculus ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?
2.7.1.25 ATP + adenosine 5-phosphosulfate PAPSS 1 is essential for the sulfonation of mucin like glycoproteins such as GlyCAM-1, CD34 and MAdCAM-1 in high endothelial venules Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.25 PAPSS 1
-
 Homo sapiens