EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.154 | expression in COS-7 cells | Mus musculus |
2.7.1.154 | expression in COS-7 cells. Specific activity of the enzyme purified from Drosophila lysate is significantly higher than that of Cpk derived from exogenous expression in COS-7 cells | Drosophila melanogaster |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.154 | Wortmannin | IC50: 11 nM | Drosophila melanogaster |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.154 | Mg2+ | the enzyme strictly requires the presence of Mg2+, inactive in presence of Mn2+ | Drosophila melanogaster | |
2.7.1.154 | additional information | inactive in presence of Mn2+ | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.137 | Drosophila melanogaster | Q9VTN5 | - |
- |
2.7.1.137 | Drosophila sp. (in: flies) | - |
- |
- |
2.7.1.154 | Drosophila melanogaster | Q7JNX6 | - |
- |
2.7.1.154 | Mus musculus | Q61194 | - |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.1.137 | phosphoprotein | the enzyme may be tyrosine-phosphorylated | Drosophila sp. (in: flies) |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.137 | ATP + 1-phosphatidylinositol | - |
Drosophila sp. (in: flies) | ADP + phosphatidylinositol 3-phosphate | - |
? | |
2.7.1.137 | ATP + 1-phosphatidylinositol | - |
Drosophila melanogaster | ADP + phosphatidylinositol 3-phosphate | - |
? | |
2.7.1.137 | ATP + phosphatidylinositol 4-phosphate | - |
Drosophila melanogaster | ADP + phosphatidylinositol 3,4-bisphosphate | - |
? | |
2.7.1.154 | ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate | - |
Drosophila melanogaster | ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | - |
? | |
2.7.1.154 | ATP + phosphatidylinositol | - |
Drosophila melanogaster | ADP + phosphatidylinositol 3-phosphate | - |
? | |
2.7.1.154 | additional information | no activity with phosphatidylinositol 4,5-diphosphate | Drosophila melanogaster | ? | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.154 | 0.000011 | - |
IC50: 11 nM | Drosophila melanogaster | Wortmannin |