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Literature summary extracted from

  • Shibasaki, F.; Fukui, Y.; Takenawa, T.
    Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases (1993), Biochem. J., 289, 227-231.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.137 phosphatidic acid enhances activity more markedly for PI 3-kinase II than for PI 3-kinase I Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.137 adenosine above 0.1 mM Bos taurus
2.7.1.137 ADP above 0.1 mM Bos taurus
2.7.1.137 AMP above 0.1 mM Bos taurus
2.7.1.137 cardiolipin
-
 Bos taurus
2.7.1.137 isoquercetin PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II Bos taurus
2.7.1.137 phosphatidylcholine strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI Bos taurus
2.7.1.137 quercetin inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.137 additional information Bos taurus enzyme plays an important role in the signalling of cell growth ?
-
 ?
2.7.1.137 additional information Bos taurus enzyme plays an important role in the signaling of cell growth ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.137 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.137 phosphoprotein putative PI 3-kinase 85000 Da subunit is phosphorylated by pp60vscr Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.137 PI3KI, monomeric form Bos taurus
2.7.1.137 PI3KII, heterodimeric form Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.137 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.137 ATP + 1-phosphatidylinositol
-
 Bos taurus ADP + phosphatidylinositol 3-phosphate
-
 ?
2.7.1.137 additional information enzyme plays an important role in the signalling of cell growth Bos taurus ?
-
 ?
2.7.1.137 additional information enzyme plays an important role in the signaling of cell growth Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.137 More two types of PI 3-kinase a monomer form, PI 3-kinase I, and a heterodimeric form, PI 3-kinase II Bos taurus