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Literature summary extracted from

  • Heesom, K.J.; Moule, S.K.; Denton, R.M.
    Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase (1998), FEBS Lett., 422, 43-46.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.27 Insulin
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.27 alpha-D-glucose 6-phosphate
-
 Rattus norvegicus
2.7.11.27 alpha-glycerophosphate
-
 Rattus norvegicus
2.7.11.27 beta-Glycerophosphate
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.27 53000
-
 SDS-PAGE, two bands Rattus norvegicus
2.7.11.27 65000
-
 SDS-PAGE, two bands Rattus norvegicus
2.7.11.27 130000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.27 ATP + [acetyl-CoA carboxylase] Rattus norvegicus
-
 ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.27 Rattus norvegicus
-
 Wistar rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.27
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.27 adipose tissue
-
 Rattus norvegicus
-
2.7.11.27 epididymis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.27 ATP + [acetyl-CoA carboxylase]
-
 Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.27 ATP + [acetyl-CoA carboxylase] no increase in acetyl-CoA carboxylase activity Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?
2.7.11.27 ATP + [acetyl-CoA carboxylase] incorporates 0.6 mol phosphate per mol of carboxylase Rattus norvegicus ADP + [acetyl-CoA carboxylase] phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.27 I-peptide kinase highly specific for acetyl-CoA carboxylase, binds selectively to the dimeric form Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.11.27 10
-
 beta-Glycerophosphate
-
 Rattus norvegicus
2.7.11.27 20
-
 alpha-glycerophosphate
-
 Rattus norvegicus
2.7.11.27 30
-
 alpha-D-glucose 6-phosphate
-
 Rattus norvegicus