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Literature summary extracted from

  • Kimura, Y.; Hirata, M.; Yamaguchi, K.; Koga, T.
    Activation by calmodulin of inositol-1,4,5-trisphosphate 3-kinase in guinea pig peritoneal macrophages (1987), Arch. Biochem. Biophys., 257, 363-369.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.127 chlorpromazine calmodulin-antagonist, inhibits Ca2+-activated enzyme activity Cavia porcellus
2.7.1.127 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 cytosol
-
Cavia porcellus 5829
-
2.7.1.127 soluble
-
Cavia porcellus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ only together with calmodulin, completely reversible Cavia porcellus
2.7.1.127 Ca2+ activation by Ca2+/calmodulin Cavia porcellus
2.7.1.127 Ca2+ not activated by free Ca2+ Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.127 partial Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 peritoneal macrophage
-
Cavia porcellus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.127 0.00029
-
-
Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
Cavia porcellus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.127 37
-
assay at Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.127 7.2
-
assay at Cavia porcellus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP
-
Cavia porcellus
2.7.1.127 Calmodulin activation by Ca2+/calmodulin Cavia porcellus