EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | chlorpromazine | calmodulin-antagonist, inhibits Ca2+-activated enzyme activity | Sus scrofa | |
2.7.1.127 | N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide | i.e. W-7, calmodulin-antagonist; inhibits Ca2+-activated enzyme activity | Sus scrofa |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.127 | cytosol | - |
Sus scrofa | 5829 | - |
2.7.1.127 | soluble | - |
Sus scrofa | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | Ca2+ | effects of Ca2+/calmodulin on enzyme activity, the calmodulin antagonists W-7 or chlorpromazine inhibit the Ca2+-enhancement of enzyme activity | Sus scrofa | |
2.7.1.127 | Ca2+ | at physiological concentrations | Sus scrofa | |
2.7.1.127 | Ca2+ | activation by Ca2+/calmodulin | Sus scrofa | |
2.7.1.127 | Mg2+ | - |
Sus scrofa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | Sus scrofa | inositol 1,4,5-trisphosphate is a second messenger | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.127 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.127 | partial | Sus scrofa |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.127 | aorta | smooth muscle | Sus scrofa | - |
2.7.1.127 | smooth muscle | aortic | Sus scrofa | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | - |
Sus scrofa | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? | |
2.7.1.127 | ATP + 1D-myo-inositol 1,4,5-trisphosphate | inositol 1,4,5-trisphosphate is a second messenger | Sus scrofa | ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate | - |
? |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 37 | - |
assay at | Sus scrofa |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.127 | 7.2 | - |
assay at | Sus scrofa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.127 | ATP | - |
Sus scrofa | |
2.7.1.127 | Calmodulin | effects of Ca2+/calmodulin on enzyme activity | Sus scrofa | |
2.7.1.127 | Calmodulin | activation by Ca2+/calmodulin | Sus scrofa |