Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Takazawa, K.; Passareiro, H.; Dumont, J.E.; Erneux, C.
    Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase in rat and bovine brain tissues (1988), Biochem. Biophys. Res. Commun., 153, 632-641.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.127 Ca2+
-
 Bos taurus
2.7.1.127 Ca2+ at 1 mM free Ca2+ Rattus norvegicus
2.7.1.127 EGTA Ca2+/calmodulin-activated enzyme Bos taurus
2.7.1.127 EGTA Ca2+/calmodulin-activated enzyme Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.127 soluble
-
 Rattus norvegicus
-
-
2.7.1.127 soluble
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.127 Ca2+ only together with calmodulin, completely reversible Rattus norvegicus
2.7.1.127 Ca2+ only together with calmodulin, completely reversible Bos taurus
2.7.1.127 Ca2+ activation by Ca2+/calmodulin Rattus norvegicus
2.7.1.127 Ca2+ activation by Ca2+/calmodulin Bos taurus
2.7.1.127 Ca2+ not activated by free Ca2+ Rattus norvegicus
2.7.1.127 Ca2+ not activated by free Ca2+ Bos taurus
2.7.1.127 Mg2+
-
 Rattus norvegicus
2.7.1.127 Mg2+
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.127 Bos taurus
-
-
-
2.7.1.127 Rattus norvegicus
-
 male sprague-dawley rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.127 cerebellum, partial Bos taurus
2.7.1.127 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.127 brain
-
 Rattus norvegicus
-
2.7.1.127 brain distribution in different anatomic regions of brain Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Rattus norvegicus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.127 ATP + 1D-myo-inositol 1,4,5-trisphosphate
-
 Bos taurus ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.127 37
-
 assay at Rattus norvegicus
2.7.1.127 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.127 7.5
-
 assay at Rattus norvegicus
2.7.1.127 7.5
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.127 ATP ATP-dependent Rattus norvegicus
2.7.1.127 ATP ATP-dependent Bos taurus
2.7.1.127 Calmodulin activation by Ca2+/calmodulin Rattus norvegicus
2.7.1.127 Calmodulin activation by Ca2+/calmodulin Bos taurus