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Literature summary extracted from

  • Zhao, X.; Yokoyama, K.; Whitten, M.E.; Huang, J.; Gelb, M.H.; Palczewski, K.
    A novel form of rhodopsin kinase from chicken retina and pineal gland (1999), FEBS Lett., 454, 115-121.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.14 GRK1 from retina and pineal gland is cloned and sequenced Gallus gallus

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.14 C588S unprenylated mutant Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.14 6
-
 rhodopsin farnesylated GRK1 Bos taurus
2.7.11.14 9
-
 rhodopsin C588S mutant GRK1 Bos taurus
2.7.11.14 30
-
 rhodopsin geranylgeranylated GRK1 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.14 membrane membrane-bound Bos taurus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.14 Mg2+
-
 Bos taurus
2.7.11.14 Mg2+
-
 Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.14 additional information
-
 amino acid sequence Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.14 ATP + rhodopsin Bos taurus
-
 ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin Gallus gallus important enzyme of phototransduction ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin Gallus gallus light-dependent initiating of deactivation of rhodopsin ADP + phosphorhodopsin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.14 Bos taurus
-
-
-
2.7.11.14 Gallus gallus O73685
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.14 side-chain modification native enzyme is farnesylated in vitro and in vivo Bos taurus
2.7.11.14 side-chain modification GRK1 contains a C-terminal consensus sequence for geranylgeranylation Gallus gallus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.14 from whole retina Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.14 eye retina Bos taurus
-
2.7.11.14 eye retina Gallus gallus
-
2.7.11.14 pineal gland
-
 Bos taurus
-
2.7.11.14 pineal gland young and adult Gallus gallus
-
2.7.11.14 pineal gland expression of retinal GRK1 Gallus gallus
-
2.7.11.14 retina
-
 Bos taurus
-
2.7.11.14 retina in rod and cone photoreceptors Gallus gallus
-
2.7.11.14 retina cone-dominant retina Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.14 ATP + rhodopsin
-
 Bos taurus ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin phosphorylates bovine rhodopsin Bos taurus ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin phosphorylates bovine rhodopsin Gallus gallus ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin highly specific for photobleached rhodopsin Gallus gallus ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin important enzyme of phototransduction Gallus gallus ADP + phosphorhodopsin
-
 ?
2.7.11.14 ATP + rhodopsin light-dependent initiating of deactivation of rhodopsin Gallus gallus ADP + phosphorhodopsin
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.14 ?
-
 Bos taurus
2.7.11.14 ? x * about 61000, SDS-PAGE Gallus gallus