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Literature summary extracted from

  • Pires, E.; Perry, S.V.; Thomas, M.A.W.
    Myosin light-chain kinase, a new enzyme from striated muscle (1974), FEBS Lett., 41, 292-296.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 additional information no activation by cAMP Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 EGTA
-
 Oryctolagus cuniculus
2.7.11.18 additional information no inhibition by 3',5'-cAMP Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.18 sarcoplasm
-
 Oryctolagus cuniculus 16528
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.18 92000
-
 x * 92000, SDS-PAGE Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + myosin light chain Oryctolagus cuniculus
-
 ADP + myosin light chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.18 partial Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 cardiac muscle
-
 Oryctolagus cuniculus
-
2.7.11.18 skeletal muscle
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.18 0.3 0.8
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of skeletal muscle Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain no substrate is casein Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain no substrate is troponin Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for regulatory or P-light-chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain highly specific for 18 kDa light chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain specific for 20 kDa light chain Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain acceptor substrates are myosin light chains of Ml3-myosin rabbit muscle Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?
2.7.11.18 ATP + myosin light chain no substrate is phosphorylase b Oryctolagus cuniculus ADP + myosin light chain phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.18 ? x * 92000, SDS-PAGE Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.18 25
-
 assay at Oryctolagus cuniculus
2.7.11.18 30
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.18 7 8
-
 Oryctolagus cuniculus