EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | deoxycholate | enhances activity of enzyme form DGK-II and DGK-III, enzyme form DGK-I is not much affected | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | octyl glucoside | enzyme form DGK-I, DGK-II and DGK-III | Homo sapiens | |
2.7.1.107 | phosphatidylcholine | enzyme form DGK-I, DGK-II and DGK-III | Homo sapiens | |
2.7.1.107 | R59022 | inhibits DGK-II and to a lesser extent DGK-III, but little affects DGK-I | Homo sapiens | |
2.7.1.107 | Triton N-101 | enzyme form DGK-I, DGK-II and DGK-III | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.107 | 0.05 | - |
diolein | pH 7.4, 30°C, enzyme form DGK-I | Homo sapiens | |
2.7.1.107 | 0.065 | - |
diolein | pH 7.4, 30°C, enzyme form DGK-II | Homo sapiens | |
2.7.1.107 | 0.08 | - |
diolein | pH 7.4, 30°C, enzyme form DGK-III | Homo sapiens | |
2.7.1.107 | 0.15 | - |
ATP | pH 7.4, 30°C, enzyme form DGK-I | Homo sapiens | |
2.7.1.107 | 0.245 | - |
ATP | pH 7.4, 30°C, enzyme form DGK-II | Homo sapiens | |
2.7.1.107 | 0.45 | - |
ATP | pH 7.4, 30°C, enzyme form DGK-III | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.1.107 | cytosol | isoenzyme DGK-I, DGK-II and DGK-II | Homo sapiens | 5829 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.107 | Mg2+ | required, optimal activity at 2.5 mM for DGK-I, 5.0 mM for DGK-II and 10.0 mM for DGK-III | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.107 | 58000 | - |
x * 58000, enzyme form DGK-III, SDS-PAGE | Homo sapiens |
2.7.1.107 | 75000 | - |
enzyme form DGK-II, gel filtration | Homo sapiens |
2.7.1.107 | 152000 | - |
x * 152000, enzyme form DGK-I, SDS-PAGE | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.107 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.107 | isoenzyme DGK-I and DGK-II, DGK-II only partially purified | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.107 | platelet | isoenzyme DGK-I, DGK-II and DGK-II | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.107 | 2.207 | - |
enzyme form DGK-II | Homo sapiens |
2.7.1.107 | 4.74 | - |
enzyme form DGK-I | Homo sapiens |
2.7.1.107 | 6.753 | - |
enzyme form DGK-III | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.107 | ATP + 2,3-dioleoyl-sn-glycerol | - |
Homo sapiens | ADP + 2,3-diacyl-sn-glycerol 1-phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.107 | ? | x * 152000, enzyme form DGK-I, SDS-PAGE | Homo sapiens |
2.7.1.107 | ? | x * 58000, enzyme form DGK-III, SDS-PAGE | Homo sapiens |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.107 | 42 | - |
5 min, complete loss of activity of DGK-II and DGK-III, about 10% loss of activity of enzyme form DGK-I | Homo sapiens |