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Literature summary extracted from

  • Racagni, G.E.; Machado de Domenech, E.E.
    Characterization of Trypanosoma cruzi hexokinase (1983), Mol. Biochem. Parasitol., 9, 181-188.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 5-thio-D-glucose marked inhibition Trypanosoma cruzi
2.7.1.1 ADP noncompetitive to glucose, competitive to ATP Trypanosoma cruzi
2.7.1.1 additional information not inhibited by D-glucose 6-phosphate Trypanosoma cruzi
2.7.1.1 N-acetyl-D-glucosamine competitive to glucose Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.09
-
 D-glucose
-
 Trypanosoma cruzi
2.7.1.1 0.4
-
 ATP
-
 Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Trypanosoma cruzi
-
 hexokinase I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 epimastigote
-
 Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 D-glucose + ATP
-
 Trypanosoma cruzi ADP + D-glucose 6-phosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 ATP
-
 Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.3
-
 N-acetyl-D-glucosamine
-
 Trypanosoma cruzi
2.7.1.1 0.4
-
 5-thio-D-glucose
-
 Trypanosoma cruzi
2.7.1.1 1.5
-
 ADP competitive to ATP Trypanosoma cruzi
2.7.1.1 7
-
 ADP noncompetitive to glucose Trypanosoma cruzi