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Literature summary extracted from

  • Liu, S.S.; Witkovsky, P.; Yang, C.Y.
    Retinal hexokinase: kinetic properties and the effect of cyclic 3,5-adenosine monophosphate (1983), J. Neurochem., 41, 1694-1701.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 D-glucose 6-phosphate marked inhibition of particulate hexokinase I activity Lithobates catesbeianus
2.7.1.1 GSSG product inhibition Lithobates catesbeianus
2.7.1.1 additional information not inhibited by 2-deoxy-D-glucose 6-phosphate Lithobates catesbeianus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.14
-
D-glucose
-
Lithobates catesbeianus
2.7.1.1 3.6
-
2-deoxy-D-glucose
-
Lithobates catesbeianus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.1 particle-bound 73% of the activity in retinas is associated with the particulate fraction and 27% with the soluble fraction Lithobates catesbeianus
-
-
2.7.1.1 soluble 73% of the activity in retinas is associated with the particulate fraction and 27% with the soluble fraction Lithobates catesbeianus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Lithobates catesbeianus
-
bullfrog, hexokinase I
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 retina
-
Lithobates catesbeianus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + 2-deoxy-D-glucose
-
Lithobates catesbeianus ADP + 2-deoxy-D-glucose 6-phosphate
-
?
2.7.1.1 D-fructose + ATP
-
Lithobates catesbeianus ADP + D-fructose 6-phosphate
-
?
2.7.1.1 D-glucose + ATP
-
Lithobates catesbeianus ADP + D-glucose 6-phosphate
-
?
2.7.1.1 D-mannose + ATP
-
Lithobates catesbeianus ADP + D-mannose 6-phosphate
-
?
2.7.1.1 additional information not: D-galactose Lithobates catesbeianus ?
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.1 AMP much less stimulation than by cAMP Lithobates catesbeianus
2.7.1.1 ATP
-
Lithobates catesbeianus
2.7.1.1 cAMP stimulates, 0.2-0.8 mM: 2fold Lithobates catesbeianus