EC Number | Application | Comment | Organism |
---|---|---|---|
2.6.1.50 | pharmacology | 2-deoxystreptamine is a component of numerous clinically important antibiotics such as gentamicin, neomycin, tobramycin, amikacin and hygromycin | Micromonospora echinospora |
EC Number | General Stability | Organism |
---|---|---|
2.6.1.50 | activity rapidly lost when dialyzed | Micromonospora echinospora |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.50 | 5,5'-dithio-bis(2-nitrobenzoic acid) | reduces specific activity by 50% | Micromonospora echinospora | |
2.6.1.50 | p-hydroxymercuribenzoate | reduces specific activity by 50% | Micromonospora echinospora |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.6.1.50 | 64000 | 76000 | gel filtration | Micromonospora echinospora |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.50 | L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | Micromonospora echinospora | 2-deoxystreptamine biosynthesis | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.50 | Micromonospora echinospora | - |
ATCC 15835 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.50 | - |
Micromonospora echinospora |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.50 | mycelium | - |
Micromonospora echinospora | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.50 | 0.24 | - |
- |
Micromonospora echinospora |
EC Number | Storage Stability | Organism |
---|---|---|
2.6.1.50 | -20°C, stored at concentrations greater than 1mg/ml, stable for several months with little loss of activity | Micromonospora echinospora |
2.6.1.50 | 4°C, inactivated within 1 month | Micromonospora echinospora |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.50 | 2-deoxystreptamine + 2-ketoglutaramate | - |
Micromonospora echinospora | 2-deoxy-keto-inosamine + L-glutamine | - |
r | |
2.6.1.50 | 2-deoxystreptamine + 2-oxoglutaramate | - |
Micromonospora echinospora | 2-deoxy-scyllo-inositol + L-glutamine | - |
r | |
2.6.1.50 | 2-deoxystreptamine + keto-scyllo-inositol | - |
Micromonospora echinospora | 2-deoxy-scyllo-inositol + amino-deoxy-keto-scyllo-inositol | - |
r | |
2.6.1.50 | aminodeoxy-scyllo-inositol + 2-oxoglutaramate | - |
Micromonospora echinospora | scyllo-inositol + L-glutamine | - |
r | |
2.6.1.50 | aminodeoxy-scyllo-inositol + keto-scyllo-inositol | - |
Micromonospora echinospora | amino-scyllo-inositol + aminodeoxy-keto-scyllo-inositol | - |
r | |
2.6.1.50 | L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | keto-scyllo-inositol | Micromonospora echinospora | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
2.6.1.50 | L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | 2-deoxystreptamine biosynthesis | Micromonospora echinospora | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
2.6.1.50 | L-glutamine + 2-oxoadipate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-2-amino-1,6-hexandioate | - |
r | |
2.6.1.50 | L-glutamine + 2-oxobutyrate | - |
Micromonospora echinospora | 2-oxoglutaramate + 2-aminobutyrate | - |
r | |
2.6.1.50 | L-glutamine + 2-oxocaproate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-norleucine | - |
r | |
2.6.1.50 | L-glutamine + 2-oxoglutaramate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-glutamine | - |
r | |
2.6.1.50 | L-glutamine + 2-oxoglutarate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-glutamate | - |
r | |
2.6.1.50 | L-glutamine + 2-oxovalerate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-norvaline | - |
r | |
2.6.1.50 | L-glutamine + DL-epi-inosose | - |
Micromonospora echinospora | 2-oxoglutaramate + amino-deoxy-inosose | - |
r | |
2.6.1.50 | L-glutamine + glyoxalate | - |
Micromonospora echinospora | 2-oxoglutaramate + glycine | - |
r | |
2.6.1.50 | L-glutamine + oxaloacetate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-aspartate | - |
r | |
2.6.1.50 | L-glutamine + pyruvate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-alanine | - |
r | |
2.6.1.50 | N3-methyl-2-deoxy-streptamine + keto-scyllo-inositol | - |
Micromonospora echinospora | 3-methylamino-2-deoxy-scyllo-inositol + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
2.6.1.50 | N3-methyl-2-deoxystreptamine + 2-oxoglutaramate | - |
Micromonospora echinospora | 3-methylamino-2-deoxy-scyllo-inositol + L-glutamine | - |
r | |
2.6.1.50 | streptamine + 2-oxoglutaramate | - |
Micromonospora echinospora | amino-scyllo-inositol + L-glutamine | - |
r | |
2.6.1.50 | streptamine + keto-scyllo-inositol | - |
Micromonospora echinospora | amino-scyllo-inositol + amino-deoxy-keto-scyllo-inositol | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.6.1.50 | aminocyclitol aminotransferase | - |
Micromonospora echinospora |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.50 | 50 | - |
heat labile, loses all activity upon incubation for 20 min | Micromonospora echinospora |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.50 | 7.5 | 8.5 | - |
Micromonospora echinospora |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.50 | 7.5 | 9 | - |
Micromonospora echinospora |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.50 | pyridoxal 5'-phosphate | - |
Micromonospora echinospora |