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Literature summary extracted from

  • Shanker, J.; Datta, K.
    Evidence of hemin as an end product inhibitor of L-alanine: 4,5-dioxovalerate transaminase in rat liver mitochondria (1985), FEBS Lett., 189, 129-132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.43 hemin
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.43 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.43 L-alanine + 4,5-dioxopentanoate Rattus norvegicus heme biosynthetic pathway 5-aminolevulinate + pyruvate
-
 ir
2.6.1.43 L-alanine + 4,5-dioxopentanoate Rattus norvegicus Wistar heme biosynthetic pathway 5-aminolevulinate + pyruvate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.43 Rattus norvegicus
-
 Wistar
-
2.6.1.43 Rattus norvegicus Wistar
-
 Wistar
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.43
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.43 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.43 L-alanine + 4,5-dioxopentanoate
-
 Rattus norvegicus 5-aminolevulinate + pyruvate
-
 ir
2.6.1.43 L-alanine + 4,5-dioxopentanoate heme biosynthetic pathway Rattus norvegicus 5-aminolevulinate + pyruvate
-
 ir
2.6.1.43 L-alanine + 4,5-dioxopentanoate
-
 Rattus norvegicus Wistar 5-aminolevulinate + pyruvate
-
 ir
2.6.1.43 L-alanine + 4,5-dioxopentanoate heme biosynthetic pathway Rattus norvegicus Wistar 5-aminolevulinate + pyruvate
-
 ir

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.43 30
-
 hemin different concentrations of alanine at fixed 4,5-dioxopentanoate concentration Rattus norvegicus
2.6.1.43 42
-
 hemin different concentrations of 4,5-dioxopentanoate concentration at fixed alanine concentration Rattus norvegicus