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Literature summary extracted from

  • Hutson, S.M.; Berkich, D.; Drown, P.; Xu, B.; Aschner, M.; LaNoue, K.F.
    Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism (1998), J. Neurochem., 71, 863-874.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.42 gabapentin structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm Homo sapiens
2.6.1.42 gabapentin structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.42 cytosol
-
 Homo sapiens 5829
-
2.6.1.42 cytosol
-
 Rattus norvegicus 5829
-
2.6.1.42 mitochondrion
-
 Homo sapiens 5739
-
2.6.1.42 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.42 L-isoleucine + 2-oxoglutarate Homo sapiens
-
 3-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-isoleucine + 2-oxoglutarate Rattus norvegicus
-
 3-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-leucine + 2-oxoglutarate Homo sapiens
-
 4-methyl-2-oxopentanoate + L-glutamate
-
 ?
2.6.1.42 L-leucine + 2-oxoglutarate Rattus norvegicus first step in the metabolism of branched-chain amino acids 4-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-valine + 2-oxoglutarate Rattus norvegicus
-
 3-methyl-2-oxobutanoate + L-glutamate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.42 Homo sapiens
-
 human
-
2.6.1.42 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.42
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.42 astrocyte
-
 Rattus norvegicus
-
2.6.1.42 brain
-
 Rattus norvegicus
-
2.6.1.42 neuron
-
 Rattus norvegicus
-
2.6.1.42 ovary
-
 Rattus norvegicus
-
2.6.1.42 placenta
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.42 L-isoleucine + 2-oxoglutarate
-
 Homo sapiens 3-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-isoleucine + 2-oxoglutarate
-
 Rattus norvegicus 3-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-leucine + 2-oxoglutarate
-
 Homo sapiens 4-methyl-2-oxopentanoate + L-glutamate
-
 ?
2.6.1.42 L-leucine + 2-oxoglutarate
-
 Homo sapiens 4-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-leucine + 2-oxoglutarate
-
 Rattus norvegicus 4-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-leucine + 2-oxoglutarate first step in the metabolism of branched-chain amino acids Rattus norvegicus 4-methyl-2-oxopentanoate + L-glutamate
-
 r
2.6.1.42 L-valine + 2-oxoglutarate
-
 Homo sapiens 3-methyl-2-oxobutanoate + L-glutamate
-
 r
2.6.1.42 L-valine + 2-oxoglutarate
-
 Rattus norvegicus 3-methyl-2-oxobutanoate + L-glutamate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.6.1.42 BCATc
-
 Homo sapiens
2.6.1.42 BCATc
-
 Rattus norvegicus
2.6.1.42 BCATm
-
 Homo sapiens
2.6.1.42 BCATm
-
 Rattus norvegicus