EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.4 | Cu2+ | strong | Homo sapiens | |
2.6.1.4 | hydroxylamine | no inhibition | Homo sapiens | |
2.6.1.4 | Isonicotinic acid hydrazide | no inhibition | Homo sapiens | |
2.6.1.4 | Maleic acid | no inhibition | Homo sapiens | |
2.6.1.4 | additional information | no inhibition by CN- | Homo sapiens | |
2.6.1.4 | PCMB | - |
Homo sapiens | |
2.6.1.4 | phenylhydrazine | pyridoxal phosphate restores activity | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.6.1.4 | 2 | - |
glyoxylate | pH 7.7, 37°C | Homo sapiens | |
2.6.1.4 | 2 | - |
glutamate | pH 7.7, 37°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.4 | glyoxylate + L-glutamate | Homo sapiens | may be involved in control of human oxalate synthesis by providing alternate pathway for glyoxylate metabolism | glycine + 2-oxoglutarate | - |
ir |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.6.1.4 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.6.1.4 | 290fold | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.6.1.4 | liver | - |
Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.6.1.4 | 0.185 | - |
purified enzyme | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.6.1.4 | glyoxylate + L-alanine | - |
Homo sapiens | glycine + pyruvate | - |
ir | |
2.6.1.4 | glyoxylate + L-glutamate | best substrate | Homo sapiens | glycine + 2-oxoglutarate | - |
ir | |
2.6.1.4 | glyoxylate + L-glutamate | may be involved in control of human oxalate synthesis by providing alternate pathway for glyoxylate metabolism | Homo sapiens | glycine + 2-oxoglutarate | - |
ir | |
2.6.1.4 | glyoxylate + L-glutamine | - |
Homo sapiens | glycine + 2-oxoglutaramate | - |
ir | |
2.6.1.4 | additional information | substrate specificity | Homo sapiens | ? | - |
? | |
2.6.1.4 | additional information | poor substrates are arginine or methionine | Homo sapiens | ? | - |
? | |
2.6.1.4 | additional information | no activity with serine, valine, aspartate, histidine, phenylalanine, tyrosine, isoleucine | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.6.1.4 | glutamate-glycine transaminase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.6.1.4 | 37 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.4 | 7.3 | - |
- |
Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.6.1.4 | 6.3 | 8.5 | about half-maximal activity at pH 6.3 and about 60% of maximal activity at pH 8.5 | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.6.1.4 | pyridoxal 5'-phosphate | required | Homo sapiens | |
2.6.1.4 | pyridoxal 5'-phosphate | tightly bound to apoenzyme | Homo sapiens | |
2.6.1.4 | pyridoxal 5'-phosphate | addition to enzyme system mostly without effect | Homo sapiens |