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Literature summary extracted from

  • Ayling, J.E.; Snell, E.E.
    Relation of structure to activity of pyridoxal analogs as substrates for pyridoxamine pyruvate transaminase (1968), Biochemistry, 7, 1626-1636.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.30 3-Deoxypyridoxal inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
2.6.1.30 4-Nitrosalicylaldehyde inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
2.6.1.30 N-Methylpyridoxal inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
2.6.1.30 O-Methylpyridoxal inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
2.6.1.30 Pyridine-4-aldehyde inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.30 additional information
-
 additional information kinetics Pseudomonas sp.
2.6.1.30 0.009
-
 5-Deoxypyridoxal pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.012
-
 pyridoxal pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.013
-
 pyridoxamine pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.014
-
 5-Deoxypyridoxamine pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.16
-
 2-Norpyridoxamine pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.35
-
 pyruvate with 3-hydroxy-4-aminomethylpyridine, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.35
-
 pyridoxamine with 3-hydroxy-4-aminomethylpyridine, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.4
-
 pyruvate with omega-methylpyridoxamine, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.42
-
 pyruvate with 5-deoxypyridoxamine, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.52
-
 pyruvate with 2-norpyridoxamine, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.58
-
 L-alanine with omega-methylpyridoxal, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.59
-
 2-norpyridoxal pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 0.89
-
 3-hydroxypyridine-4-aldehyde pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 1.3
-
 omega-methylpyridoxal pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 1.6
-
 L-alanine with pyridoxal, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 1.9
-
 L-alanine with 5-deoxypyridoxal, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 2.7
-
 L-alanine with 2-norpyridoxal, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 7.4
-
 pyruvate with 3-hydroxy-4-aminomethylpyridine, pH 8.9, 25°C Pseudomonas sp.
2.6.1.30 64.5
-
 L-alanine with 3-hydroxypyridine-4-aldehyde, pH 8.9, 25°C Pseudomonas sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.30 pyridoxamine + pyruvate Pseudomonas sp.
-
 pyridoxal + L-alanine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.30 Pseudomonas sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.30 2-norpyridoxal + L-alanine
-
 Pseudomonas sp. 2-norpyridoxamine + pyruvate
-
 r
2.6.1.30 3-hydroxypyridine-4-aldehyde + L-alanine
-
 Pseudomonas sp. 3-hydroxy-4-aminomethylpyridine + pyruvate
-
 r
2.6.1.30 5-deoxypyridoxal + L-alanine
-
 Pseudomonas sp. 5-deoxypyridoxamine + pyruvate
-
 r
2.6.1.30 additional information not active with: 3-deoxypyridoxal, pyridine-4-aldehyde, O-methylpyridoxal, 4-nitrosalicylaldehyde Pseudomonas sp. ?
-
 ?
2.6.1.30 omega-methylpyridoxal + L-alanine i.e. 3-hydroxy-5-hydroxymethyl-2-ethylpyridine-4-carboxaldehyde Pseudomonas sp. omega-methylpyridoxamine + pyruvate
-
 r
2.6.1.30 pyridoxamine + pyruvate
-
 Pseudomonas sp. pyridoxal + L-alanine
-
 r