Literature summary extracted from

Flores, N.; Xiao, J.; Berry, A.; Bolivar, F.; Valle, F.
Pathway engineering for the production of aromatic compouds in Escherichia coli (1996), Nat. Biotechnol., 14, 620-623.

Application

EC Number	Application	Comment	Organism
2.5.1.54	biotechnology	increased production of aromatic amino acids in E. coli mutants with modified phosphoenolpyruvate metabolism and enhanced transketolase activity	Escherichia coli
2.5.1.54	biotechnology	E. coli strains, overproducing the enzyme, excrete it to the medium, which can also be used as a bioindicator for enhanced carbon commitment into the pathway	Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.54	phosphoenolpyruvate + D-erythrose 4-phosphate + H2O	Escherichia coli	first enzyme of the aromatic amino acid biosynthesis	2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.54	Escherichia coli	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.54	phosphoenolpyruvate + D-erythrose 4-phosphate + H2O	-	Escherichia coli	2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate	-	?
2.5.1.54	phosphoenolpyruvate + D-erythrose 4-phosphate + H2O	first enzyme of the aromatic amino acid biosynthesis	Escherichia coli	2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate	-	?

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Release 2023.1 (January 2023)