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Literature summary extracted from

  • Berry, A.; Johnson, J.L.; Jensen, R.A.
    Phenylalanine hydroxylase and isozymes of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in relationship to the phylogenetic position of Pseudomonas acidovorans (Ps. Sp. ATCC 11299a) (1985), Arch. Microbiol., 141, 32-39.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.54 Phe 0.04 mM, 50% inhibition of DAHP synthase-phe; L-Phe; Phe-sensitive isozyme Delftia acidovorans
2.5.1.54 Tyr 0.04 mM, 50% inhibition of DAHP synthase-tyr; L-Tyr; Tyr-sensitive isozyme Delftia acidovorans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.54 0.2
-
 phosphoenolpyruvate DAHP synthase-phe, pH 7.0, 37°C Delftia acidovorans
2.5.1.54 0.26
-
 phosphoenolpyruvate DAHP synthase-tyr, pH 7.0, 37°C Delftia acidovorans
2.5.1.54 0.77
-
 D-erythrose 4-phosphate DAHP synthase-tyr, pH 7.0, 37°C Delftia acidovorans
2.5.1.54 0.87
-
 D-erythrose 4-phosphate DAHP synthase-phe, pH 7.0, 37°C Delftia acidovorans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.54 67000
-
 DAHP synthase-phe, gel filtration Delftia acidovorans
2.5.1.54 251000
-
 DAHP synthase-tyr, gel filtration Delftia acidovorans

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.54 Comamonas testosteroni
-
 strain ATCC 17409
-
2.5.1.54 Delftia acidovorans
-
 strain ATCC 11299a, two distinct regulatory isoenzymes: DAHP synthase-phe and DAHP synthase-tyr
-
2.5.1.54 Delftia acidovorans
-
 i.e. Comamonas terrigena
-
2.5.1.54 Hydrogenophaga palleronii
-
 strain ATCC 17724
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Comamonas testosteroni 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Delftia acidovorans 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?
2.5.1.54 phosphoenolpyruvate + D-erythrose 4-phosphate + H2O
-
 Hydrogenophaga palleronii 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.54 37
-
 assay at Delftia acidovorans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.54 6.8 7.2 DAHP synthase-phe Delftia acidovorans
2.5.1.54 7
-
 DAHP synthase-tyr Delftia acidovorans