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Literature summary extracted from

  • Hoffman, A.R.; Ciaranello, R.D.; Axelrod, J.
    Substrate and inhibitor kinetics of bovine phenylethanolamine-N-methyltransferase (1975), Biochem. Pharmacol., 24, 544-546.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 dopamine competitive inhibition with respect to phenylethanolamine Bos taurus
2.1.1.28 epinephrine noncompetitive with normetanephrine as substrate Bos taurus
2.1.1.28 norepinephrine noncompetitive inhibition with phenylethanolamine as substrate, competitive inhibition with normetanephrine as substrate Bos taurus
2.1.1.28 Phenylethylamine competitive inhibition with respect to phenylethanolamine Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.28
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
 Bos taurus
-
2.1.1.28 adrenal medulla
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.28 dopamine + S-adenosyl-L-methionine
-
 Bos taurus ? + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 epinephrine + S-adenosyl-L-methionine
-
 Bos taurus ? + D-adenosylhomocysteine
-
 ?
2.1.1.28 norepinephrine + S-adenosyl-L-methionine
-
 Bos taurus epinephrine + S-adenosyl-L-homocysteine
-
 ?
2.1.1.28 phenylethanolamine + S-adenosyl-L-methionine
-
 Bos taurus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.28 0.0059
-
 norepinephrine noncompetitive with phenylethanolamine Bos taurus
2.1.1.28 3.6
-
 Phenylethylamine competitive with phenylethanolamine Bos taurus
2.1.1.28 8
-
 dopamine competitive with phenylethanolamine Bos taurus