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Literature summary extracted from

  • Axelrod, J.
    Purification and properties of phenylethanolamine-N-methyltransferase (1962), J. Biol. Chem., 237, 1657-1660.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.28 PCMB
-
Bos taurus
2.1.1.28 PCMB 0.01 mM, complete inhibition Macaca mulatta
2.1.1.28 PCMB
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.28 0.05
-
normetanephrine
-
Macaca mulatta

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.28 Bos taurus
-
-
-
2.1.1.28 Cavia porcellus
-
-
-
2.1.1.28 Felis catus
-
-
-
2.1.1.28 Macaca mulatta
-
-
-
2.1.1.28 Oryctolagus cuniculus
-
-
-
2.1.1.28 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.28
-
Macaca mulatta

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.28 adrenal gland
-
Rattus norvegicus
-
2.1.1.28 adrenal gland
-
Bos taurus
-
2.1.1.28 adrenal gland
-
Oryctolagus cuniculus
-
2.1.1.28 adrenal gland adrenal medulla has considerably more activity than the cortex Macaca mulatta
-
2.1.1.28 adrenal medulla
-
Bos taurus
-
2.1.1.28 adrenal medulla
-
Macaca mulatta
-
2.1.1.28 heart
-
Rattus norvegicus
-
2.1.1.28 heart weak activity Oryctolagus cuniculus
-
2.1.1.28 heart weak activity Macaca mulatta
-

Storage Stability

EC Number Storage Stability Organism
2.1.1.28 -10°C, stable for at least 1 month Macaca mulatta

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.28 3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine
-
Oryctolagus cuniculus N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 3,4-dichlorophenylethanolamine + S-adenosyl-L-methionine
-
Macaca mulatta N-methyl-3,4-dichlorophenylethanolamine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 3,4-dichlorophenylethylenediamine + S-adenosyl-L-methionine
-
Macaca mulatta ? + S-adenosyl-L-homocysteine
-
?
2.1.1.28 3,4-dihydroxynorephedrine + S-adenosyl-L-methionine 18% of the activity with normetanephrine Macaca mulatta 3,4-dihydroxyephedrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 3-chloro-4-hydroxyphenylethanolamine + S-adenosyl-L-methionine
-
Macaca mulatta ? + S-adenosyl-L-homocysteine
-
?
2.1.1.28 4-hydroxynorephedrine + S-adenosyl-L-methionine 18% of the activity with normetanephrine Macaca mulatta 4-hydroxyephedrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 D-norepinephrine + S-adenosyl-L-methionine
-
Oryctolagus cuniculus epinephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 D-norepinephrine + S-adenosyl-L-methionine 15% of the activity with normetanephrine Macaca mulatta epinephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 DL-m-hydroxyphenylethanolamine + S-adenosyl-L-methionine 60% of the activity with normetanephrine Macaca mulatta neosynephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 DL-neo-synephrine + S-adenosyl-L-methionine 20% of the activity with normetanephrine Macaca mulatta 3-hydroxy-alpha-[(dimethylamine)methyl]benzenemethanol + S-adenosyl-L-homocysteine
-
?
2.1.1.28 DL-octopamine + S-adenosyl-L-methionine 18% of the activity with normetanephrine Macaca mulatta ? + S-adenosyl-L-homocysteine
-
?
2.1.1.28 L-norephedrine + S-adenosyl-L-methionine 14% of the activity with normetanephrine Macaca mulatta ephedrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 L-norepinephrine + S-adenosyl-L-methionine
-
Oryctolagus cuniculus epinephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 L-norepinephrine + S-adenosyl-L-methionine 21% of the activity with normetanephrine Macaca mulatta epinephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 normetanephrine + S-adenosyl-L-methionine
-
Bos taurus metanephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 normetanephrine + S-adenosyl-L-methionine
-
Macaca mulatta metanephrine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 phenylethanolamine + S-adenosyl-L-methionine
-
Bos taurus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 phenylethanolamine + S-adenosyl-L-methionine
-
Oryctolagus cuniculus N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
?
2.1.1.28 phenylethanolamine + S-adenosyl-L-methionine 72% of the activity with normetanephrine Macaca mulatta N-methylphenylethanolamine + S-adenosyl-L-homocysteine
-
?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.28 7.5 8.2 phosphate buffer Macaca mulatta
2.1.1.28 8 9 Tris buffer Macaca mulatta