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Literature summary extracted from

  • Santini, F.; Chopra, I.J.; Hurd, R.E.; Chua Teco, G.N.
    A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species (1992), Endocrinology, 131, 830-834.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Bos taurus
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Cavia porcellus
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Gallus gallus
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Homo sapiens
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Mus musculus
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Ovis aries
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Rattus sp.
1.21.99.4 aurothioglucose type I, selenium-containing enzyme, competitive Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.99.4 0.21
-
 3,3',5'-triiodothyronine type I Rattus sp.
1.21.99.4 0.21
-
 3,3',5'-triiodothyronine DTT 10 mM Rattus sp.
1.21.99.4 0.24
-
 3,3',5'-triiodothyronine DTT 10 mM Bos taurus
1.21.99.4 0.24
-
 3,3',5'-triiodothyronine type I, liver Bos taurus
1.21.99.4 0.28
-
 3,3',5'-triiodothyronine DTT 10 mM Mus musculus
1.21.99.4 0.28
-
 3,3',5'-triiodothyronine type I, liver Mus musculus
1.21.99.4 0.33
-
 3,3',5'-triiodothyronine DTT 10 mM Sus scrofa
1.21.99.4 0.33
-
 3,3',5'-triiodothyronine type I, liver Sus scrofa
1.21.99.4 0.51
-
 3,3',5'-triiodothyronine DTT 10 mM Cavia porcellus
1.21.99.4 0.51
-
 3,3',5'-triiodothyronine type I, liver Cavia porcellus
1.21.99.4 0.66
-
 3,3',5'-triiodothyronine DTT 10 mM Gallus gallus
1.21.99.4 0.66
-
 3,3',5'-triiodothyronine type I,l iver Gallus gallus
1.21.99.4 0.69
-
 3,3',5'-triiodothyronine DTT 10 mM Ovis aries
1.21.99.4 0.69
-
 3,3',5'-triiodothyronine type I, liver Ovis aries
1.21.99.4 0.7
-
 3,3',5'-triiodothyronine DTT 10 mM Homo sapiens
1.21.99.4 0.7
-
 3,3',5'-triiodothyronine type I, liver Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2 Gallus gallus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Cavia porcellus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Mus musculus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Homo sapiens
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Sus scrofa
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Bos taurus
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Ovis aries
-
 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 Rattus sp. isoenzyme type I 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Bos taurus
-
-
-
1.21.99.4 Cavia porcellus
-
-
-
1.21.99.4 Gallus gallus
-
-
-
1.21.99.4 Homo sapiens
-
-
-
1.21.99.4 Mus musculus
-
-
-
1.21.99.4 Ovis aries
-
-
-
1.21.99.4 Rattus sp.
-
 Rattus norvegicus
-
1.21.99.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 liver
-
 Gallus gallus
-
1.21.99.4 liver
-
 Cavia porcellus
-
1.21.99.4 liver
-
 Mus musculus
-
1.21.99.4 liver
-
 Homo sapiens
-
1.21.99.4 liver
-
 Sus scrofa
-
1.21.99.4 liver
-
 Bos taurus
-
1.21.99.4 liver
-
 Ovis aries
-
1.21.99.4 liver
-
 Rattus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.21.99.4 0.0001
-
 isoenzyme type I Homo sapiens
1.21.99.4 0.0001
-
 isoenzyme type I Ovis aries
1.21.99.4 0.0002
-
 isoenzyme type I Gallus gallus
1.21.99.4 0.0002
-
 isoenzyme type I Bos taurus
1.21.99.4 0.0003
-
 isoenzyme type I Sus scrofa
1.21.99.4 0.0004
-
 isoenzyme type I Mus musculus
1.21.99.4 0.002
-
 isoenzyme type I Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Gallus gallus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Cavia porcellus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Mus musculus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Homo sapiens 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Sus scrofa 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Bos taurus 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2
-
 Ovis aries 3,3'-diiodothyronine + iodide + A + H+
-
 ?
1.21.99.4 3,3',5'-triiodothyronine + AH2 isoenzyme type I Rattus sp. 3,3'-diiodothyronine + iodide + A + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.21.99.4 More substrate binding unit type I Sus scrofa
1.21.99.4 More substrate binding unit type I 31 kD Homo sapiens
1.21.99.4 More substrate binding unit type I 29 kD, SDS-PAGE Gallus gallus
1.21.99.4 More substrate binding unit type I 29 kD, SDS-PAGE Mus musculus
1.21.99.4 More substrate binding unit type I 29 kD, SDS-PAGE Bos taurus
1.21.99.4 More substrate binding unit type I 29 kD, SDS-PAGE Ovis aries
1.21.99.4 More substrate binding unit type I 29 kD, SDS-PAGE Rattus sp.
1.21.99.4 More substrate binding unit type I 33 kD Cavia porcellus

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 Iodothyronine 5'-monodeiodinase isoenzyme type I Rattus sp.