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Literature summary extracted from

  • Malykh, Y.N.; Shaw, L.; Schauer, R.
    The role of CMP-N-acetylneuraminic acid hydroxylase in determining the level of N-glycolylneuraminic acid in porcine tissues (1998), Glycoconjugate J., 15, 885-893.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Sus scrofa the biosynthesis of the sialic acid N-glycolylneuraminic acid occurs by the action of cytidine monophosphate-N-acetylneuraminate hydroxylase. Incorporation of N-glycoloylneuraminic acid into glycoconjugates is generally controlled by the amount of hydroxylase protein expressed in a tissue CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 heart weak activity Sus scrofa
-
1.14.18.2 kidney weak activity Sus scrofa
-
1.14.18.2 liver weak activity Sus scrofa
-
1.14.18.2 lung
-
 Sus scrofa
-
1.14.18.2 lymph node
-
 Sus scrofa
-
1.14.18.2 small intestine
-
 Sus scrofa
-
1.14.18.2 spleen
-
 Sus scrofa
-
1.14.18.2 submandibular gland
-
 Sus scrofa
-
1.14.18.2 thymus
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
 Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 the biosynthesis of the sialic acid N-glycolylneuraminic acid occurs by the action of cytidine monophosphate-N-acetylneuraminate hydroxylase. Incorporation of N-glycoloylneuraminic acid into glycoconjugates is generally controlled by the amount of hydroxylase protein expressed in a tissue Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 NADH
-
 Sus scrofa