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Literature summary extracted from

  • Schlenzka, W.; Shaw, L.; Schauer, R.
    Catalytic properties of the CMP-N-acetylneuraminic acid hydroxylase from the starfish Asterias rubens: comparison with the mammalian enzyme (1993), Biochim. Biophys. Acta, 1161, 131-138.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.18.2 ascorbate activates Asterias rubens
1.14.18.2 dithiothreitol activates Asterias rubens
1.14.18.2 glutathione activates Asterias rubens
1.14.18.2 additional information no activation by non-ionic detergents Asterias rubens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.2 1,10-phenanthroline
-
Asterias rubens
1.14.18.2 azide
-
Asterias rubens
1.14.18.2 Ca2+ 0.5 mM, 12% inhibition Asterias rubens
1.14.18.2 CHAPS 15 mM, complete inhibition Asterias rubens
1.14.18.2 cholic acid 10 mM, 89% inhibition Asterias rubens
1.14.18.2 decylglucopyranoside 5 mM, 22% inhibition Asterias rubens
1.14.18.2 ferrozine
-
Asterias rubens
1.14.18.2 Hg2+ slight inhibition Asterias rubens
1.14.18.2 KCN
-
Asterias rubens
1.14.18.2 Mn2+ 0.5 mM, slight inhibition Asterias rubens
1.14.18.2 additional information not inhibited by increased ionic strength, no inhibition by 1 M NaCl Asterias rubens
1.14.18.2 octylglucopyranoside 30 mM, 48% inhibition Asterias rubens
1.14.18.2 Tiron
-
Asterias rubens
1.14.18.2 Zwittergent 3-12 5 mM, 40% inhibition Asterias rubens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.18.2 0.018
-
CMP-N-acetylneuraminate 25°C Asterias rubens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.2 Iron the enzyme contains a non-haem iron cofactor Asterias rubens

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Asterias rubens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 alimentary canal
-
Asterias rubens
-
1.14.18.2 body wall
-
Asterias rubens
-
1.14.18.2 gonad
-
Asterias rubens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
Asterias rubens CMP-N-glycoloylneuraminate + NAD+ + H2O
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.18.2 25 33
-
Asterias rubens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.14.18.2 15 43 15°C: about 55% of maximal activity, 43°C: about 30% of maximal activity Asterias rubens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.2 6 6.4
-
Asterias rubens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.14.18.2 5.6 6.8 about 60% of maximal activity at pH 5.6 and pH 6.8 Asterias rubens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 NADH most effective cofactor, optimal activity at 0.4 mM NADH, higher concentrations are slightly inhibitory Asterias rubens