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Literature summary extracted from

  • Shaw, L.; Schneckenburger, P.; Schlenzka, W.; Carlsen, J.; Christiansen, K.; Juergensen, D.; Schauer, R.
    CMP-N-acetylneuraminic acid hydroxylase from mouse liver and pig submandibular glands. Interaction with membrane-bound and soluble cytochrome b5-dependent electron transport chains (1994), Eur. J. Biochem., 219, 1001-1011.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.2 anti-(rat cytochrome b5) antiserum
-
 Mus musculus
1.14.18.2 anti-(rat cytochrome b5) antiserum
-
 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.18.2 56000
-
 gel filtration Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Mus musculus
-
 CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Sus scrofa
-
 CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Bos taurus
-
 CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Bos taurus
-
-
-
1.14.18.2 Mus musculus
-
-
-
1.14.18.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 liver
-
 Mus musculus
-
1.14.18.2 liver
-
 Sus scrofa
-
1.14.18.2 submandibular gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 pure hydrophilic cytochrome b5 interacts more effectively with the hydroxylase than isolated amphiphytic cytochrome b5 Mus musculus CMP-N-glycoloylneuraminate + ferricytrochrome b5 + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + ferrocytochrome b5 + O2 pure hydrophilic cytochrome b5 interacts more effectively with the hydroxylase than isolated amphiphytic cytochrome b5 Sus scrofa CMP-N-glycoloylneuraminate + ferricytrochrome b5 + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
 Mus musculus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
 Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
 Bos taurus CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 ferrocytochrome b5 pure hydrophilic cytochrome b5 interacts more effectively with the hydroxylase than isolated amphiphytic cytochrome b5 Mus musculus
1.14.18.2 ferrocytochrome b5 pure hydrophilic cytochrome b5 interacts more effectively with the hydroxylase than isolated amphiphytic cytochrome b5 Sus scrofa
1.14.18.2 NADH
-
 Mus musculus
1.14.18.2 NADH
-
 Sus scrofa
1.14.18.2 NADH
-
 Bos taurus