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Literature summary extracted from

  • Shaw, L.; Schauer, R.
    The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid (1988), Biol. Chem. Hoppe-Seyler, 369, 477-486.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 Sus scrofa
-
 CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.2 submandibular gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.2 CMP-N-acetylneuraminate + 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin + O2 less effectiove than NADH or NADPH Sus scrofa CMP-N-glycoloylneuraminate + ?
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + ascorbic acid + O2 less effective than NADH or NADPH Sus scrofa CMP-N-glycoloylneuraminate + dehydroascorbate + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2
-
 Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADH + O2 NADPH and NADH are by far the most effective cofactors Sus scrofa CMP-N-glycoloylneuraminate + NAD+ + H2O
-
 ?
1.14.18.2 CMP-N-acetylneuraminate + NADPH + O2 NADPH and NADH are by far the most effective cofactors Sus scrofa CMP-N-glycoloylneuraminate + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.18.2 NADH NADPH and NADH are by far the most effective cofactors Sus scrofa
1.14.18.2 NADPH NADPH and NADH are by far the most effective cofactors Sus scrofa