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Literature summary extracted from

  • Kilty, I.; Logan, A.; Vickers, P.J.
    Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase (1999), Eur. J. Biochem., 266, 83-93.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 isoenzyme 15S-LOb and a splice variant of 15-LOb, baculovirus/insect cell expression system Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.33 0.01
-
 lipoic acid splice variant 15-LOb1 Homo sapiens
1.13.11.33 0.025
-
 arachidonic acid splice variant 15-LOb1 Homo sapiens
1.13.11.33 1.1
-
 arachidonic acid splice variant 15-LOb2 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.33 Iron nonheme iron dioxygenase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Homo sapiens alternative splicing of 15S-lipoxygenase provides a further level of regulation of fatty acid metabolism (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 lung
-
 Homo sapiens
-
1.13.11.33 lymph node
-
 Homo sapiens
-
1.13.11.33 lymphocyte
-
 Homo sapiens
-
1.13.11.33 ovary
-
 Homo sapiens
-
1.13.11.33 prostate
-
 Homo sapiens
-
1.13.11.33 spinal cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 arachidonate + O2 alternative splicing of 15S-lipoxygenase provides a further level of regulation of fatty acid metabolism Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 linoleic acid + O2
-
 Homo sapiens 13-hydroxylinoleic acid
-
 ?
1.13.11.33 lipoic acid + O2
-
 Homo sapiens ?
-
 r