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Literature summary extracted from

  • Burrall, B.A.; Cheung, M.; Chiu, A.; Goetzel, E.J.
    Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes (1988), J. Invest. Dermatol., 91, 294-297.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 5,8,11,14-Eicosatetraynoic acid 0.0009 mM, 50% inhibition Homo sapiens
1.13.11.33 nordihydroguaiaretic acid 0.002 mM, 50% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.33 0.0095
-
 linoleic acid
-
 Homo sapiens
1.13.11.33 0.0106
-
 arachidonic acid
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.33 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.33 Ca2+ optimal activity at 2 mM or above Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 keratinocyte neonatal foreskin cultured keratinocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 linoleic acid + O2
-
 Homo sapiens 13-hydroxylinoleic acid
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.33 6.7 7.3
-
 Homo sapiens