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Literature summary extracted from

  • Burns, R.O.; Umbarger, H.E.; Gross, S.R.
    The biosythesis of leucine. III. The conversation of alpha-hydroxy-beta-carboxyisocaproate to alpha-ketoisocaproate (1963), Biochemistry, 2, 1053-1058.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.85 Ba2+
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 Ca2+
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 Zn2+
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.85 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.85
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.85 (2R,3S)-3-isopropylmalate + NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-oxoisocaproate + NADH + H+ + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.85 9.5
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.85 NAD+
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 NADP+ can not substitute for NAD+ Salmonella enterica subsp. enterica serovar Typhimurium