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Literature summary extracted from
- The effects of progesterone and pregnanedione on the reductive metabolism of dihydrotestosterone in human skin (1980), J. Steroid Biochem., 13, 645-651.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.278 | 5alpha-pregnan-3,20-dione | - |
Homo sapiens |  |
| 1.1.1.278 | progesterone | - |
Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.278 | cytosol | - |
Homo sapiens | 5829 | - |
| 1.1.1.278 | microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.278 | 5alpha-pregnan-3,20-dione + NADPH | Homo sapiens | - |
3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.278 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.278 | skin | pubic | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.278 | 5alpha-pregnan-3,20-dione + NAD(P)H | - |
Homo sapiens | 3beta-hydroxy-5alpha-pregnan-20-one + NAD(P)+ | - |
r | |
| 1.1.1.278 | 5alpha-pregnan-3,20-dione + NADPH | - |
Homo sapiens | 3beta-hydroxy-5alpha-pregnane-20-one + NADP+ | - |
r | |
| 1.1.1.278 | additional information | progesterone is no substrate | Homo sapiens | ? | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.278 | NAD+ | less effective than NADP+ | Homo sapiens | |
| 1.1.1.278 | NADH | less effective than NADPH | Homo sapiens | |
| 1.1.1.278 | NADP+ | - |
Homo sapiens | |
| 1.1.1.278 | NADPH | - |
Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.278 | 0.0095 | - |
5alpha-pregnan-3,20-dione | in presence of NADH | Homo sapiens | |
| 1.1.1.278 | 0.0125 | - |
5alpha-pregnan-3,20-dione | in presence of NADPH | Homo sapiens | |
| 1.1.1.278 | 0.035 | - |
progesterone | in presence of NADH | Homo sapiens | |
| 1.1.1.278 | 0.066 | - |
progesterone | in presence of NADPH | Homo sapiens | |
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Release 2023.1 (January 2023)
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