Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Schloendorff, J.; Becherer, J.D.; Blobel, C.P.
    Intracellular maturation and localization of the tumor necrosis factor alpha convertase (TACE) (2000), Biochem. J., 347, 131-138.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.86 phorbol ester
-
 Mus musculus
3.4.24.86 phorbol ester
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.86 cDNA fragment coding for the prodomain of human TACE, expressed and purified from a baculoviral expression system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.86 1,10-phenanthroline
-
 Chlorocebus aethiops
3.4.24.86 1,10-phenanthroline
-
 Homo sapiens
3.4.24.86 1,10-phenanthroline
-
 Mus musculus
3.4.24.86 BB 94
-
 Chlorocebus aethiops
3.4.24.86 BB 94
-
 Homo sapiens
3.4.24.86 BB 94
-
 Mus musculus
3.4.24.86 EndoH full-length TACE is sensitive to EndoH, mature TACE is resistant Chlorocebus aethiops
3.4.24.86 EndoH full-length TACE is sensitive to EndoH, mature TACE is resistant Homo sapiens
3.4.24.86 EndoH full-length TACE is sensitive to EndoH, mature TACE is resistant Mus musculus
3.4.24.86 Hydroxamate
-
 Chlorocebus aethiops
3.4.24.86 Hydroxamate
-
 Homo sapiens
3.4.24.86 Hydroxamate
-
 Mus musculus
3.4.24.86 TACE-pro domain pro domain is an inhibitor of the catalytic domain Homo sapiens
3.4.24.86 TACE-pro domain
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.86 cell surface
-
 Mus musculus 9986
-
3.4.24.86 cell surface
-
 Homo sapiens 9986
-
3.4.24.86 cytoplasm cytoplasmic tail Mus musculus 5737
-
3.4.24.86 cytoplasm cytoplasmic tail Homo sapiens 5737
-
3.4.24.86 cytoplasm cytoplasmic tail Chlorocebus aethiops 5737
-
3.4.24.86 endoplasmic reticulum
-
 Mus musculus 5783
-
3.4.24.86 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.4.24.86 endoplasmic reticulum
-
 Chlorocebus aethiops 5783
-
3.4.24.86 Golgi apparatus proximal Golgi Mus musculus 5794
-
3.4.24.86 Golgi apparatus proximal Golgi Homo sapiens 5794
-
3.4.24.86 Golgi apparatus proximal Golgi Chlorocebus aethiops 5794
-
3.4.24.86 membrane
-
 Chlorocebus aethiops 16020
-
3.4.24.86 membrane membrane-bound Mus musculus 16020
-
3.4.24.86 membrane membrane-bound Homo sapiens 16020
-
3.4.24.86 perinuclear space
-
 Mus musculus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.86 Zn2+ zinc metalloprotease Mus musculus
3.4.24.86 Zn2+ zinc metalloprotease Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.86 80000
-
 migrates as a 80 kDa protein under non-reducing conditions, immunoprecipitation Mus musculus
3.4.24.86 80000
-
 migrates as a 80 kDa protein under non-reducing conditions, immunoprecipitation Homo sapiens
3.4.24.86 80000
-
 migrates as a 80 kDa protein under non-reducing conditions, immunoprecipitation Chlorocebus aethiops
3.4.24.86 100000
-
 100 kDa reduced form represents mature TACE lacking the prodomain, immunoprecipitation Mus musculus
3.4.24.86 100000
-
 100 kDa reduced form represents mature TACE lacking the prodomain, immunoprecipitation Homo sapiens
3.4.24.86 120000
-
 full length form of TACE migrates as a 120 kDa protein under reducing conditions, immunoprecipitation Mus musculus
3.4.24.86 120000
-
 full length form of TACE migrates as a 120 kDa protein under reducing conditions, immunoprecipitation Homo sapiens
3.4.24.86 120000
-
 full length form of TACE migrates as a 120 kDa protein under reducing conditions, immunoprecipitation Chlorocebus aethiops
3.4.24.86 160000
-
 identified with prodomain antibody in COS-7 membrane preparations Chlorocebus aethiops

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.86 Chlorocebus aethiops
-
 african green monkey, COS-7, an SV40 transformed kidney cell line
-
3.4.24.86 Homo sapiens
-
 human monocytic cell line THP-1
-
3.4.24.86 Mus musculus
-
 mouse
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.86 recombinant enzyme Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.86 kidney
-
 Mus musculus
-
3.4.24.86 kidney
-
 Homo sapiens
-
3.4.24.86 kidney
-
 Chlorocebus aethiops
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.86 beta-amyloid precursor protein + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 beta-amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 L-selectin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 L-selectin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 additional information
-
 Homo sapiens ?
-
 ?
3.4.24.86 additional information angiotensin converting enzyme is not cleaved by TACE Mus musculus ?
-
 ?
3.4.24.86 p75 tumour necrosis factor receptor + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 p75 tumour necrosis factor receptor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
3.4.24.86 proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.86 transforming growth factor alpha + H2O
-
 Chlorocebus aethiops ?
-
 ?