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Literature summary extracted from

  • Lalmanach, G.; Boulange, A.; Serveau, C.; Lecaille, F.; Scharfstein, J.; Gauthier, F.; Authie, E.
    Congopain from Trypanosoma congolense: drug target and vaccine candidate (2002), Biol. Chem., 383, 739-749.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.51 2-mercaptoethanol activates Trypanosoma congolense
3.4.22.51 dithiothreitol activates Trypanosoma congolense
3.4.22.51 L-cysteine activates Trypanosoma congolense

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.51 L-trans-epoxysuccinylleucylamido(4-guanidino)butane
-
 Trypanosoma congolense
3.4.22.51 leupeptin
-
 Trypanosoma congolense
3.4.22.51 additional information pro-region of the trypanosomal enzyme inhibits the enzyme function, cystatins and kininogens are inhibitors, overview: inhibitors Trypanosoma congolense

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.51 33000
-
 SDS-PAGE Trypanosoma congolense

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.51 Trypanosoma congolense Q26909
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.22.51
-
 Trypanosoma congolense

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.51 benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
-
 Trypanosoma congolense ?
-
 ?
3.4.22.51 additional information no substrate: benzyloxycarbonyl-Arg-Arg-aminomethyl coumarin Trypanosoma congolense ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.51 6
-
-
 Trypanosoma congolense

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.22.51 4 8.5
-
 Trypanosoma congolense

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.4.22.51 additional information
-
 stable at alkaline and acid pH Trypanosoma congolense

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.51 additional information
-
 additional information Ki for cystatins and kininogens in the picomolar range Trypanosoma congolense