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Literature summary extracted from

  • Cazzulo, J.J.; Bravo, M.; Raimond, A.; Engstroem, U.; Lindeberg, G.; Hellman, U.
    Hydrolysis of synthetic peptides by cruzipain, the major cysteine proteinase from Trypanosoma cruzi, provides evidence for self-processing and the possibility of more specific substrates for the enzyme (1996), Cell. Mol. Biol., 42, 691-696.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.51 0.033
-
 N-carbobenzoxy-VVR-4-nitroanilide pH 9 Trypanosoma cruzi
3.4.22.51 0.066
-
 benzoyl-PFR-4-nitroanilide
-
 Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.51 Trypanosoma cruzi Q598P5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.51 benzoyl-PFR-4-nitroanilide + H2O
-
 Trypanosoma cruzi ?
-
 ?
3.4.22.51 KEEASSAVVGGPG + H2O
-
 Trypanosoma cruzi ?
-
 ?
3.4.22.51 KEEASSAVVRGPG + H2O
-
 Trypanosoma cruzi ?
-
 ?
3.4.22.51 N-carbobenzoxy-Val-Val-Arg-4-nitroanilide + H2O excellent substrate Trypanosoma cruzi ?
-
 ?
3.4.22.51 N-carbobenzoxy-VVR-4-nitroanilide + H2O
-
 Trypanosoma cruzi N-carbobenzoxy-VVR + 4-nitroaniline
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.51 6.8
-
 KEEASSAVVGGPG as substrate Trypanosoma cruzi
3.4.22.51 6.8
-
 KEEASSAVVRGPG as substrate Trypanosoma cruzi