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Literature summary extracted from

  • Szabo, C.M.; Matsumura, Y.; Fukura, S.; Martin, M.B.; Sanders, J.M.; Sengupta, S.; Cieslak, J.A.; Loftus, T.C.; Lea, C.R.; Lee, H.J.; Koohang, A.; Coates, R.M.; Sagami, H.; Oldfield, E.
    Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents (2002), J. Med. Chem., 45, 2185-2196.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.29
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.29 3-azafarnesyl diphosphate 0.00074 mM, 50% inhibition Homo sapiens
2.5.1.29 3-azageranyl diphosphate 0.24 mM, 50% inhibition Homo sapiens
2.5.1.29 3-azageranylgeranyl diphosphate 0.00014 mM, 50% inhibition Homo sapiens
2.5.1.29 3-azahomofarnesyl diphosphate 0.00031 mM, 50% inhibition Homo sapiens
2.5.1.29 3-azahomogeranylgeranyl diphosphate 0.00037 mM, 50% inhibition Homo sapiens
2.5.1.29 homorisedronate i.e. NE58051, 0.41 mM, 50% inhibition Homo sapiens
2.5.1.29 ibandronate 0.083 mM, 50% inhibition Homo sapiens
2.5.1.29 additional information geranylgeranyl diphosphate synthase is inhibited by a variety of bisphosphonates Homo sapiens
2.5.1.29 pamidronate 0.18 mM, 50% inhibition Homo sapiens
2.5.1.29 risedronate i.e. NE58095, 0.35 mM, 50% inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate Homo sapiens
-
 geranylgeranyl diphosphate + diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 2 isopentenyl diphosphate Homo sapiens
-
 geranylgeranyl diphosphate + 2 diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.29 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
 Homo sapiens geranylgeranyl diphosphate + diphosphate
-
 ?
2.5.1.29 geranyl diphosphate + 2 isopentenyl diphosphate
-
 Homo sapiens geranylgeranyl diphosphate + 2 diphosphate
-
 ?