BRENDA - Enzyme Database show

Membrane-bound lecithin-retinol acyltransferase

Rando, R.R.; Biochem. Biophys. Res. Commun. 292, 1243-1250 (2002)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
additional information
not readily inhibitable by serine-directed chemical reagents; readily inactivated by organomercurials in the micromolar range
Bos taurus
2.3.1.135
additional information
-
Homo sapiens
2.3.1.135
additional information
-
Rattus norvegicus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.135
microsome
-
Homo sapiens
-
-
2.3.1.135
microsome
-
Rattus norvegicus
-
-
2.3.1.135
microsome
-
Bos taurus
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
Homo sapiens
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
Bos taurus
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
Rattus norvegicus
important role in absorption and storage of vitamin A
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Bos taurus
-
-
-
2.3.1.135
Homo sapiens
-
-
-
2.3.1.135
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.3.1.135
affinity labeling with all-trans-retinyl-alpha-bromoacetate, SDS electrophoresis, prior to affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification; affinity labeling with N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone, precipitation and gel electrophoresis, prior to affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification; labeling with N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone, affinity chromatography, avidin, prior to affinity chromatography or affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification
Bos taurus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638625
Homo sapiens
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638625
Homo sapiens
-
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638625
Rattus norvegicus
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638625
Rattus norvegicus
?
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638625
Bos taurus
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638625
Bos taurus
-
2.3.1.135
additional information
all-trans-retinol is a far better substrate than 11-cis-retinol
638625
Bos taurus
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638625
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638625
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
the fatty acid in the 2-position is important in substrate recognition
638625
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
the fatty acid in the 2-position is important in substrate recognition
638625
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
the fatty acid in the 2-position is important in substrate recognition
638625
Bos taurus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638625
Homo sapiens
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638625
Bos taurus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
important role in absorption and storage of vitamin A
638625
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638625
Homo sapiens
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638625
Homo sapiens
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638625
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638625
Rattus norvegicus
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638625
Bos taurus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638625
Bos taurus
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.135
additional information
not readily inhibitable by serine-directed chemical reagents; readily inactivated by organomercurials in the micromolar range
Bos taurus
2.3.1.135
additional information
-
Homo sapiens
2.3.1.135
additional information
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.3.1.135
microsome
-
Homo sapiens
-
-
2.3.1.135
microsome
-
Rattus norvegicus
-
-
2.3.1.135
microsome
-
Bos taurus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
Homo sapiens
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
Bos taurus
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
Rattus norvegicus
important role in absorption and storage of vitamin A
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.135
affinity labeling with all-trans-retinyl-alpha-bromoacetate, SDS electrophoresis, prior to affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification; affinity labeling with N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone, precipitation and gel electrophoresis, prior to affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification; labeling with N-Boc-L-biocytinyl-11-aminoundecan chloromethylketone, affinity chromatography, avidin, prior to affinity chromatography or affinity labelling, incubation with cholesterol chloroacetate to block nucleophilic reagents, or streptavidin column to remove endogenously biotinylated proteins enhance protein purification
Bos taurus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638625
Homo sapiens
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638625
Homo sapiens
-
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638625
Rattus norvegicus
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638625
Rattus norvegicus
?
2.3.1.135
dipalmitoylphosphatidylcholine + all-trans-retinol
-
638625
Bos taurus
all-trans-retinyl palmitate + 2-palmitoylglycerophosphocholine
-
638625
Bos taurus
-
2.3.1.135
additional information
all-trans-retinol is a far better substrate than 11-cis-retinol
638625
Bos taurus
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638625
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
only fatty acyl group at the sn-1 is transferred
638625
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
the fatty acid in the 2-position is important in substrate recognition
638625
Homo sapiens
?
-
-
-
-
2.3.1.135
additional information
the fatty acid in the 2-position is important in substrate recognition
638625
Rattus norvegicus
?
-
-
-
-
2.3.1.135
additional information
the fatty acid in the 2-position is important in substrate recognition
638625
Bos taurus
?
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638625
Homo sapiens
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638625
Bos taurus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
important role in absorption and storage of vitamin A
638625
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638625
Homo sapiens
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638625
Homo sapiens
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638625
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638625
Rattus norvegicus
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638625
Bos taurus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638625
Bos taurus
-