BRENDA - Enzyme Database show

Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens

Guo, X.; Knudsen, B.S.; Peehl, D.M.; Ruiz, A.; Bok, D.; Rando, R.R.; Rhim, J.S.; Nanus, D.M.; Gudas, L.J.; Cancer Res. 62, 1654-1661 (2002)

Data extracted from this reference:

Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
breast adenocarcinoma cell
breast carcinoma cells have lower LRAT activity
Homo sapiens
-
2.3.1.135
carcinoma cell
skin, these cells have lower LRAT activity
Homo sapiens
-
2.3.1.135
prostate
practically no activity in prostatic cancer cells
Homo sapiens
-
2.3.1.135
prostate cancer cell
adenocarcinoma, LRAT is downregulated as a result of oncogenic transformation
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638622
Homo sapiens
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
638622
Homo sapiens
r
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
breast adenocarcinoma cell
breast carcinoma cells have lower LRAT activity
Homo sapiens
-
2.3.1.135
carcinoma cell
skin, these cells have lower LRAT activity
Homo sapiens
-
2.3.1.135
prostate
practically no activity in prostatic cancer cells
Homo sapiens
-
2.3.1.135
prostate cancer cell
adenocarcinoma, LRAT is downregulated as a result of oncogenic transformation
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638622
Homo sapiens
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
638622
Homo sapiens
r