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Literature summary extracted from

  • Zolfaghari, R.; Ross, A.C.
    Lecithin:retinol acyltransferase from mouse and rat liver: cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid (2000), J. Lipid Res., 41, 2024-2034.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.135 retinoic acid
-
 Mus musculus
2.3.1.135 retinoic acid
-
 Rattus norvegicus
2.3.1.135 Vitamin A regulates LRAT activity in the liver but not in the small intestine Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.135 expression in HEK-293T cells Mus musculus
2.3.1.135 expression in HEK-293T cells Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 phosphatidylcholine + all-trans-retinol Mus musculus
-
 all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol Rattus norvegicus
-
 all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Mus musculus Q9JI60 Balb-C line, vitamin A sufficient and deficient diet fed
-
2.3.1.135 Rattus norvegicus Q9JI61 vitamin A deficient and sufficient diet fed
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 adrenal gland mRNA expression Rattus norvegicus
-
2.3.1.135 intestine
-
 Rattus norvegicus
-
2.3.1.135 liver
-
 Mus musculus
-
2.3.1.135 liver undetectable in vitamin A depleted rats Rattus norvegicus
-
2.3.1.135 lung mRNA expression Rattus norvegicus
-
2.3.1.135 skeletal muscle mRNA expression Rattus norvegicus
-
2.3.1.135 small intestine
-
 Rattus norvegicus
-
2.3.1.135 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 phosphatidylcholine + all-trans-retinol
-
 Mus musculus all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?
2.3.1.135 phosphatidylcholine + all-trans-retinol
-
 Rattus norvegicus all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
 ?
2.3.1.135 phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
 Mus musculus 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
 ?
2.3.1.135 phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
 Rattus norvegicus 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.135 monomer
-
 Rattus norvegicus
2.3.1.135 monomer 1 × 25800, fully active catalytically Mus musculus