BRENDA - Enzyme Database show

Lecithin:retinol acyltransferase from mouse and rat liver: cDNA cloning and liver-specific regulation by dietary vitamin A and retinoic acid

Zolfaghari, R.; Ross, A.C.; J. Lipid Res. 41, 2024-2034 (2000)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.135
retinoic acid
-
Mus musculus
2.3.1.135
retinoic acid
-
Rattus norvegicus
2.3.1.135
Vitamin A
regulates LRAT activity in the liver but not in the small intestine
Rattus norvegicus
Cloned(Commentary)
EC Number
Commentary
Organism
2.3.1.135
expression in HEK-293T cells
Mus musculus
2.3.1.135
expression in HEK-293T cells
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
Mus musculus
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
Rattus norvegicus
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Mus musculus
Q9JI60
Balb-C line, vitamin A sufficient and deficient diet fed
-
2.3.1.135
Rattus norvegicus
Q9JI61
vitamin A deficient and sufficient diet fed
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
adrenal gland
mRNA expression
Rattus norvegicus
-
2.3.1.135
intestine
-
Rattus norvegicus
-
2.3.1.135
liver
undetectable in vitamin A depleted rats
Rattus norvegicus
-
2.3.1.135
liver
-
Mus musculus
-
2.3.1.135
lung
mRNA expression
Rattus norvegicus
-
2.3.1.135
skeletal muscle
mRNA expression
Rattus norvegicus
-
2.3.1.135
small intestine
-
Rattus norvegicus
-
2.3.1.135
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638619
Mus musculus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638619
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638619
Mus musculus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638619
Mus musculus
?
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638619
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638619
Rattus norvegicus
?
Subunits
EC Number
Subunits
Commentary
Organism
2.3.1.135
monomer
1 × 25800, fully active catalytically
Mus musculus
2.3.1.135
monomer
-
Rattus norvegicus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.135
retinoic acid
-
Mus musculus
2.3.1.135
retinoic acid
-
Rattus norvegicus
2.3.1.135
Vitamin A
regulates LRAT activity in the liver but not in the small intestine
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
2.3.1.135
expression in HEK-293T cells
Mus musculus
2.3.1.135
expression in HEK-293T cells
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
Mus musculus
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
Rattus norvegicus
-
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
adrenal gland
mRNA expression
Rattus norvegicus
-
2.3.1.135
intestine
-
Rattus norvegicus
-
2.3.1.135
liver
undetectable in vitamin A depleted rats
Rattus norvegicus
-
2.3.1.135
liver
-
Mus musculus
-
2.3.1.135
lung
mRNA expression
Rattus norvegicus
-
2.3.1.135
skeletal muscle
mRNA expression
Rattus norvegicus
-
2.3.1.135
small intestine
-
Rattus norvegicus
-
2.3.1.135
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638619
Mus musculus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + all-trans-retinol
-
638619
Rattus norvegicus
all-trans-retinyl acyl esters + 2-acylglycerophosphocholine
-
-
-
-
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638619
Mus musculus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638619
Mus musculus
?
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638619
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638619
Rattus norvegicus
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
2.3.1.135
monomer
1 × 25800, fully active catalytically
Mus musculus
2.3.1.135
monomer
-
Rattus norvegicus