BRENDA - Enzyme Database show

Lecithin:retinol acyltransferase and retinyl ester hydrolase activities are differentially regulated by retinoids and have distinct distributions between hepatocyte and nonparenchymal cell fractions of rat liver

Matsuura, T.; Gad, M.Z.; Harrison, E.H.; Ross, A.C.; J. Nutr. 127, 218-224 (1997)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.135
N-(4-hydroxyphenyl)-retinamide
necessary dose, 0.5 mg; restores normal level of LRAT activity in vitamin A depleted rats
Rattus norvegicus
2.3.1.135
retinol
-
Rattus norvegicus
2.3.1.135
Vitamin A
-
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.135
Rattus norvegicus
-
vitamin A deficient and sufficient diet fed
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
liver
nonparenchymal cells LRAT activity is approximately 10 fold greater than the hepatocyte LRAT activity from both vitamin A-sufficient and retinoid acid treated vitamin A-depleted rats
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.3.1.135
0.0000001
-
nonparenchymal cell fraction LRAT activity and hepatocyte cell fraction LRAT activity for vitamin A-deficient rats
Rattus norvegicus
2.3.1.135
0.0000012
-
hepatocyte cell fraction LRAT activity for vitamin A-deficient rats treated with retinoic acid
Rattus norvegicus
2.3.1.135
0.000003
-
hepatocyte fraction LRAT activity of vitamin A-sufficient rats
Rattus norvegicus
2.3.1.135
0.0000054
-
hepatocyte cell fraction LRAT activity for vitamin A-deficient rats treated with N-(4-hydroxyphenyl)-retinamide
Rattus norvegicus
2.3.1.135
0.0000132
-
nonparenchymal cell fraction LRAT activity for vitamin A-deficient rats treated with retinoic acid
Rattus norvegicus
2.3.1.135
0.0000309
-
nonparenchymal cell fraction LRAT activity for vitamin A-sufficient rats
Rattus norvegicus
2.3.1.135
0.0000553
-
nonparenchymal cell fraction LRAT activity for vitamin A-deficient rats treated with N-(4-hydroxyphenyl)-retinamide
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638616
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638616
Rattus norvegicus
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.135
N-(4-hydroxyphenyl)-retinamide
necessary dose, 0.5 mg; restores normal level of LRAT activity in vitamin A depleted rats
Rattus norvegicus
2.3.1.135
retinol
-
Rattus norvegicus
2.3.1.135
Vitamin A
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.3.1.135
liver
nonparenchymal cells LRAT activity is approximately 10 fold greater than the hepatocyte LRAT activity from both vitamin A-sufficient and retinoid acid treated vitamin A-depleted rats
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.3.1.135
0.0000001
-
nonparenchymal cell fraction LRAT activity and hepatocyte cell fraction LRAT activity for vitamin A-deficient rats
Rattus norvegicus
2.3.1.135
0.0000012
-
hepatocyte cell fraction LRAT activity for vitamin A-deficient rats treated with retinoic acid
Rattus norvegicus
2.3.1.135
0.000003
-
hepatocyte fraction LRAT activity of vitamin A-sufficient rats
Rattus norvegicus
2.3.1.135
0.0000054
-
hepatocyte cell fraction LRAT activity for vitamin A-deficient rats treated with N-(4-hydroxyphenyl)-retinamide
Rattus norvegicus
2.3.1.135
0.0000132
-
nonparenchymal cell fraction LRAT activity for vitamin A-deficient rats treated with retinoic acid
Rattus norvegicus
2.3.1.135
0.0000309
-
nonparenchymal cell fraction LRAT activity for vitamin A-sufficient rats
Rattus norvegicus
2.3.1.135
0.0000553
-
nonparenchymal cell fraction LRAT activity for vitamin A-deficient rats treated with N-(4-hydroxyphenyl)-retinamide
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.3.1.135
phosphatidylcholine + retinol-(cellular-retinol-binding-protein)
-
638616
Rattus norvegicus
2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein)
-
638616
Rattus norvegicus
?